Seroatlas · Human Serome Atlas

TMBIM6

Bax inhibitor 1

Also known as: BAXI1, BI-1, BI1_HUMAN, TEGT

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P55061
Gene
TMBIM6
Ensembl
ENSG00000139644
Chromosome
12
Canonical length
237 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables endoribonuclease inhibitor activity and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of RNA splicing; negative regulation of intracellular signal transduction; and response to L-glutamate. Acts upstream of or within negative regulation of calcium ion transport into cytosol. Located in endoplasmic reticulum membrane. Biomarker of cervical squamous cell carcinoma and prostate carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

237 residues, UniProt reviewed canonical sequence.

>P55061|TMBIM6
     1  MNIFDRKINF DALLKFSHIT PSTQQHLKKV YASFALCMFV AAAGAYVHMV THFIQAGLLS
    61  ALGSLILMIW LMATPHSHET EQKRLGLLAG FAFLTGVGLG PALEFCIAVN PSILPTAFMG
   121  TAMIFTCFTL SALYARRRSY LFLGGILMSA LSLLLLSSLG NVFFGSIWLF QANLYVGLVV
   181  MCGFVLFDTQ LIIEKAEHGD QDYIWHCIDL FLDFITVFRK LMMILAMNEK DKKKEKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMBIM6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
1,686 nTPM

Expression across tissuesHPA

Tissue

  • liver: 1,686 nTPM
  • kidney: 1,068 nTPM
  • choroid plexus: 889 nTPM
  • epididymis: 605 nTPM
  • thyroid gland: 558 nTPM
  • parathyroid gland: 543 nTPM

Single-cell type

  • late spermatids: 3,973 nCPM
  • esophageal apical cells: 2,843 nCPM
  • hepatocytes: 2,811 nCPM
  • early spermatids: 1,708 nCPM
  • parietal cells: 1,639 nCPM
  • enterocytes: 1,602 nCPM

Immune cell

  • total PBMC: 1,808 nTPM
  • neutrophil: 1,241 nTPM
  • basophil: 897 nTPM
  • eosinophil: 796 nTPM
  • non-classical monocyte: 772 nTPM
  • classical monocyte: 748 nTPM

Brain region

  • choroid plexus: 806 nTPM
  • white matter: 513 nTPM
  • medulla oblongata: 493 nTPM
  • thalamus: 476 nTPM
  • hypothalamus: 454 nTPM
  • basal ganglia: 448 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0.02
gnomAD missense Z
0.59
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMBIM6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMBIM6 as an antibody target. Whether an autoantibody or antibody against TMBIM6 could matter depends on whether native TMBIM6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMBIM6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMBIM6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMBIM6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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