Seroatlas · Human Serome Atlas

CLTA

Clathrin light chain A

Also known as: CLCA_HUMAN, Lca

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P09496
Gene
CLTA
Ensembl
ENSG00000122705
Chromosome
9
Canonical length
248 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location
Golgi apparatus,Vesicles,Endosomes,Lysosomes

OverviewNCBI Gene

Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

248 residues, UniProt reviewed canonical sequence.

>P09496|CLTA
     1  MAELDPFGAP AGAPGGPALG NGVAGAGEED PAAAFLAQQE SEIAGIENDE AFAILDGGAP
    61  GPQPHGEPPG GPDAVDGVMN GEYYQESNGP TDSYAAISQV DRLQSEPESI RKWREEQMER
   121  LEALDANSRK QEAEWKEKAI KELEEWYARQ DEQLQKTKAN NRVADEAFYK QPFADVIGYV
   181  TNINHPCYSL EQAAEEAFVN DIDESSPGTE WERVARLCDF NPKSSKQAKD VSRMRSVLIS
   241  LKQAPLVH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLTA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
230 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 230 nTPM
  • spinal cord: 226 nTPM
  • cerebral cortex: 205 nTPM
  • esophagus: 199 nTPM
  • midbrain: 197 nTPM
  • ovary: 197 nTPM

Single-cell type

  • syncytiotrophoblasts: 1,536 nCPM
  • hofbauer cells: 1,406 nCPM
  • esophageal apical cells: 1,201 nCPM
  • cytotrophoblasts: 1,160 nCPM
  • migrating cytotrophoblasts: 931 nCPM
  • oocytes: 824 nCPM

Immune cell

  • intermediate monocyte: 240 nTPM
  • myeloid DC: 224 nTPM
  • classical monocyte: 223 nTPM
  • total PBMC: 210 nTPM
  • plasmacytoid DC: 193 nTPM
  • non-classical monocyte: 193 nTPM

Brain region

  • white matter: 161 nTPM
  • pons: 156 nTPM
  • medulla oblongata: 145 nTPM
  • cerebellum: 144 nTPM
  • hypothalamus: 143 nTPM
  • spinal cord: 141 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.96
gnomAD missense Z
0.8
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLTA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLTA as an antibody target. Whether an autoantibody or antibody against CLTA could matter depends on whether native CLTA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLTA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CLTA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLTA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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