BBC3

Protein identityUniProt · HPA

UniProt accession

Q96PG8

Gene

BBC3

Ensembl

ENSG00000105327

Chromosome

19

Canonical length

261 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Cytosol

OverviewNCBI Gene

This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

261 residues, UniProt reviewed canonical sequence.

>Q96PG8|BBC3
     1  MKFGMGSAQA CPCQVPRAAS TTWVPCQICG PRERHGPRTP GGQLPGARRG PGPRRPAPLP
    61  ARPPGALGSV LRPLRARPGC RPRRPHPAAR CLPLRPHRPT RRHRRPGGFP LAWGSPQPAP
   121  RPAPGRSSAL ALAGGAAPGV ARAQRPGGSG GRSHPGGPGS PRGGGTVGPG DRGPAAADGG
   181  RPQRTVRAAE TRGAAAAPPL TLEGPVQSHH GTPALTQGPQ SPRDGAQLGA CTRPVDVRDS
   241  GGRPLPPPDT LASAGDFLCT M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BBC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.76

Highest tissue expression

10 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.59

gnomAD pLI

0

gnomAD missense Z

0.15

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• execution phase of apoptosis
• intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
• positive regulation of intrinsic apoptotic signaling pathway
• positive regulation of release of cytochrome c from mitochondria
• release of cytochrome c from mitochondria

Molecular functions

• ATPase binding

Cellular components

• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Bcl-2-binding component 3

InteractionsUniProt · HPA

Protein binding partners of BBC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BCL2L1
• MCL1
• BCL2A1
• BCL2