Seroatlas · Human Serome Atlas

HRK

Activator of apoptosis harakiri

Also known as: DP5, HRK_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00198
Gene: HRK
Ensembl: ENSG00000135116
Chromosome: 12
Canonical length: 91 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

Canonical amino-acid sequenceUniProt

91 residues, UniProt reviewed canonical sequence.

>O00198|HRK
     1  MCPCPLHRGR GPPAVCACSA GRLGLRSSAA QLTAARLKAL GDELHQRTMW RRRARSRRAP
    61  APGALPTYWP WLCAAAQVAA LAAWLLGRRN L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HRK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 7.6 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 7.6 nTPM
hippocampal formation: 7.4 nTPM
thyroid gland: 3.6 nTPM
choroid plexus: 3.2 nTPM
thymus: 3.2 nTPM
pituitary gland: 2.6 nTPM

Single-cell type

somatotrophs: 100 nCPM
adrenal medulla cells: 75 nCPM
epididymal efferent duct ciliated cells: 45 nCPM
salivary duct cells: 42 nCPM
choroid plexus epithelial cells: 41 nCPM
thyrotrophs: 38 nCPM

Immune cell

naive B-cell: 3.9 nTPM
memory B-cell: 3.7 nTPM
eosinophil: 1.3 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

hippocampal formation: 30 nTPM
cerebral cortex: 15 nTPM
basal ganglia: 13 nTPM
choroid plexus: 9.9 nTPM
amygdala: 9.6 nTPM
hypothalamus: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0.36
gnomAD missense Z: 0.7
DepMap mean gene effect: -0.36
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Apoptosis regulator, Bcl-2, BH3 motif, conserved site
Activator of apoptosis harakiri
Activator of apoptosis harakiri

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HRK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HRK as an antibody target. Whether an autoantibody or antibody against HRK could matter depends on whether native HRK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HRK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HRK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...