Seroatlas · Human Serome Atlas

HEBP2

Heme-binding protein 2

Also known as: C6orf34, HEBP2_HUMAN, SOUL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y5Z4
Gene: HEBP2
Ensembl: ENSG00000051620
Chromosome: 6
Canonical length: 205 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress. [provided by RefSeq, May 2016]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>Q9Y5Z4|HEBP2
     1  MAEPLQPDPG AAEDAAAQAV ETPGWKAPED AGPQPGSYEI RHYGPAKWVS TSVESMDWDS
    61  AIQTGFTKLN SYIQGKNEKE MKIKMTAPVT SYVEPGSGPF SESTITISLY IPSEQQFDPP
   121  RPLESDVFIE DRAEMTVFVR SFDGFSSAQK NQEQLLTLAS ILREDGKVFD EKVYYTAGYN
   181  SPVKLLNRNN EVWLIQKNEP TKENE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HEBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 156 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 156 nTPM
breast: 142 nTPM
skeletal muscle: 125 nTPM
esophagus: 122 nTPM
vagina: 77 nTPM
skin: 75 nTPM

Single-cell type

esophageal apical cells: 2,707 nCPM
esophageal suprabasal cells: 725 nCPM
hepatocytes: 652 nCPM
extravillous trophoblasts: 534 nCPM
breast secretory cells: 462 nCPM
suprabasal keratinocytes: 458 nCPM

Immune cell

neutrophil: 15 nTPM
intermediate monocyte: 8.2 nTPM
classical monocyte: 7.9 nTPM
myeloid DC: 7.5 nTPM
T-reg: 6.4 nTPM
basophil: 5.6 nTPM

Brain region

thalamus: 40 nTPM
midbrain: 28 nTPM
hypothalamus: 25 nTPM
pons: 23 nTPM
choroid plexus: 23 nTPM
medulla oblongata: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
gnomAD missense Z: 0.11
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

heme binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HEBP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HEBP2 as an antibody target. Whether an autoantibody or antibody against HEBP2 could matter depends on whether native HEBP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HEBP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HEBP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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