Seroatlas · Human Serome Atlas

BIK

Bcl-2-interacting killer

Also known as: BIK_HUMAN, NBK

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13323
Gene: BIK
Ensembl: ENSG00000100290
Chromosome: 22
Canonical length: 160 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

160 residues, UniProt reviewed canonical sequence.

>Q13323|BIK
     1  MSEVRPLSRD ILMETLLYEQ LLEPPTMEVL GMTDSEEDLD PMEDFDSLEC MEGSDALALR
    61  LACIGDEMDV SLRAPRLAQL SEVAMHSLGL AFIYDQTEDI RDVLRSFMDG FTTLKENIMR
   121  FWRSPNPGSW VSCEQVLLAL LLLLALLLPL LSGGLHLLLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BIK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 17 nTPM
stomach: 13 nTPM
esophagus: 11 nTPM
prostate: 11 nTPM
lymph node: 11 nTPM
tonsil: 11 nTPM

Single-cell type

oocytes: 479 nCPM
tuft cells: 473 nCPM
esophageal apical cells: 299 nCPM
endometrial secretory cells: 124 nCPM
gastric progenitor cells: 96 nCPM
fallopian secretory cells: 72 nCPM

Immune cell

eosinophil: 73 nTPM
plasmacytoid DC: 59 nTPM
memory B-cell: 17 nTPM
naive B-cell: 12 nTPM
neutrophil: 11 nTPM
myeloid DC: 10 nTPM

Brain region

cerebellum: 3.3 nTPM
hippocampal formation: 2.8 nTPM
basal ganglia: 2.5 nTPM
cerebral cortex: 2.4 nTPM
amygdala: 2 nTPM
pons: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: 0.11
DepMap mean gene effect: 0.29
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Apoptosis regulator, Bcl-2, BH3 motif, conserved site
Bcl-2-interacting killer
Bcl2-interacting killer, BH3-domain containing

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BIK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BIK as an antibody target. Whether an autoantibody or antibody against BIK could matter depends on whether native BIK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BIK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BIK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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