Seroatlas · Human Serome Atlas

FBXO5

F-box only protein 5

Also known as: EMI1, FBX5, FBX5_HUMAN, Fbxo31

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UKT4
Gene: FBXO5
Ensembl: ENSG00000112029
Chromosome: 6
Canonical length: 447 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

447 residues, UniProt reviewed canonical sequence.

>Q9UKT4|FBXO5
     1  MSRRPCSCAL RPPRCSCSAS PSAVTAAGRP RPSDSCKEES STLSVKMKCD FNCNHVHSGL
    61  KLVKPDDIGR LVSYTPAYLE GSCKDCIKDY ERLSCIGSPI VSPRIVQLET ESKRLHNKEN
   121  QHVQQTLNST NEIEALETSR LYEDSGYSSF SLQSGLSEHE EGSLLEENFG DSLQSCLLQI
   181  QSPDQYPNKN LLPVLHFEKV VCSTLKKNAK RNPKVDREML KEIIARGNFR LQNIIGRKMG
   241  LECVDILSEL FRRGLRHVLA TILAQLSDMD LINVSKVSTT WKKILEDDKG AFQLYSKAIQ
   301  RVTENNNKFS PHASTREYVM FRTPLASVQK SAAQTSLKKD AQTKLSNQGD QKGSTYSRHN
   361  EFSEVAKTLK KNESLKACIR CNSPAKYDCY LQRATCKREG CGFDYCTKCL CNYHTTKDCS
   421  DGKLLKASCK IGPLPGTKKS KKNLRRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 42 nTPM
thymus: 25 nTPM
lymph node: 14 nTPM
tonsil: 14 nTPM
appendix: 6.9 nTPM
placenta: 6 nTPM

Single-cell type

erythrocyte progenitors: 94 nCPM
monocyte progenitors: 90 nCPM
neutrophil progenitors: 52 nCPM
megakaryocyte progenitors: 48 nCPM
early primary spermatocytes: 47 nCPM
oocytes: 46 nCPM

Immune cell

NK-cell: 7.1 nTPM
T-reg: 6.6 nTPM
memory CD8 T-cell: 5.2 nTPM
memory B-cell: 5.1 nTPM
naive B-cell: 5 nTPM
naive CD8 T-cell: 4.9 nTPM

Brain region

cerebellum: 4 nTPM
white matter: 2.7 nTPM
choroid plexus: 2.6 nTPM
thalamus: 2.3 nTPM
hypothalamus: 2.1 nTPM
pons: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.97
gnomAD missense Z: 0.82
DepMap mean gene effect: -1.31
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXO5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXO5 as an antibody target. Whether an autoantibody or antibody against FBXO5 could matter depends on whether native FBXO5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXO5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXO5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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