Seroatlas · Human Serome Atlas

ANAPC13

Anaphase-promoting complex subunit 13

Also known as: APC13, APC13_HUMAN, DKFZP566D193, SWM1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BS18
Gene: ANAPC13
Ensembl: ENSG00000129055
Chromosome: 3
Canonical length: 74 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria,Cytosol

OverviewNCBI Gene

This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008]

Canonical amino-acid sequenceUniProt

74 residues, UniProt reviewed canonical sequence.

>Q9BS18|ANAPC13
     1  MDSEVQRDGR ILDLIDDAWR EDKLPYEDVA IPLNELPEPE QDNGGTTESV KEQEMKWTDL
    61  ALQYLHENVP PIGN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANAPC13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 113 nTPM

Expression across tissuesHPA

Tissue

kidney: 113 nTPM
epididymis: 108 nTPM
choroid plexus: 108 nTPM
heart muscle: 92 nTPM
thyroid gland: 89 nTPM
skeletal muscle: 86 nTPM

Single-cell type

parietal cells: 279 nCPM
gastric chief cells: 208 nCPM
oocytes: 198 nCPM
late spermatids: 145 nCPM
decidual stromal cells: 132 nCPM
epididymal principal cells: 131 nCPM

Immune cell

neutrophil: 229 nTPM
non-classical monocyte: 111 nTPM
basophil: 111 nTPM
intermediate monocyte: 108 nTPM
classical monocyte: 96 nTPM
naive CD4 T-cell: 94 nTPM

Brain region

choroid plexus: 76 nTPM
hypothalamus: 52 nTPM
pons: 49 nTPM
medulla oblongata: 44 nTPM
midbrain: 41 nTPM
white matter: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
gnomAD missense Z: 0.13
DepMap mean gene effect: -0.52
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

anaphase-promoting complex

Protein domainsUniProt · Pfam · InterPro

Apc13
Apc13p protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANAPC13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANAPC13 as an antibody target. Whether an autoantibody or antibody against ANAPC13 could matter depends on whether native ANAPC13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANAPC13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANAPC13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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