Seroatlas · Human Serome Atlas

ANAPC15

Anaphase-promoting complex subunit 15

Also known as: APC15, APC15_HUMAN, C11orf51, DKFZP564M082, HSPC020

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P60006
Gene: ANAPC15
Ensembl: ENSG00000110200
Chromosome: 11
Canonical length: 121 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Involved in anaphase-promoting complex-dependent catabolic process; protein polyubiquitination; and regulation of mitotic cell cycle spindle assembly checkpoint. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

121 residues, UniProt reviewed canonical sequence.

>P60006|ANAPC15
     1  MSTLFPSLFP RVTETLWFNL DRPCVEETEL QQQEQQHQAW LQSIAEKDNN LVPIGKPASE
    61  HYDDEEEEDD EDDEDSEEDS EDDEDMQDMD EMNDYNESPD DGEVNEVDME GNEQDQDQWM
   121  I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANAPC15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 94 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 94 nTPM
skeletal muscle: 93 nTPM
amygdala: 87 nTPM
cerebral cortex: 83 nTPM
basal ganglia: 83 nTPM
midbrain: 77 nTPM

Single-cell type

esophageal basal cells: 143 nCPM
early primary spermatocytes: 138 nCPM
undifferentiated spermatogonia: 128 nCPM
differentiating spermatogonia: 124 nCPM
esophageal suprabasal cells: 113 nCPM
hofbauer cells: 104 nCPM

Immune cell

classical monocyte: 174 nTPM
T-reg: 158 nTPM
myeloid DC: 154 nTPM
eosinophil: 141 nTPM
total PBMC: 128 nTPM
plasmacytoid DC: 123 nTPM

Brain region

cerebral cortex: 44 nTPM
hypothalamus: 43 nTPM
white matter: 42 nTPM
basal ganglia: 41 nTPM
midbrain: 41 nTPM
spinal cord: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0.3
gnomAD missense Z: 1.22
DepMap mean gene effect: -0.59
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Anaphase-promoting complex subunit 15
Anaphase-promoting complex subunit 15

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANAPC15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANAPC15 as an antibody target. Whether an autoantibody or antibody against ANAPC15 could matter depends on whether native ANAPC15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANAPC15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANAPC15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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