Seroatlas · Human Serome Atlas

UBE2C

Ubiquitin-conjugating enzyme E2 C

Also known as: UBCH10, UBE2C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00762
Gene
UBE2C
Ensembl
ENSG00000175063
Chromosome
20
Canonical length
179 aa
Protein class
Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

179 residues, UniProt reviewed canonical sequence.

>O00762|UBE2C
     1  MASQNRDPAA TSVAAARKGA EPSGGAARGP VGKRLQQELM TLMMSGDKGI SAFPESDNLF
    61  KWVGTIHGAA GTVYEDLRYK LSLEFPSGYP YNAPTVKFLT PCYHPNVDTQ GNICLDILKE
   121  KWSALYDVRT ILLSIQSLLG EPNIDSPLNT HAAELWKNPT AFKKYLQETY SKQVTSQEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
106 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 106 nTPM
  • bone marrow: 74 nTPM
  • tonsil: 65 nTPM
  • lymph node: 42 nTPM
  • esophagus: 40 nTPM
  • rectum: 29 nTPM

Single-cell type

  • megakaryocytes: 680 nCPM
  • gastric progenitor cells: 528 nCPM
  • extravillous trophoblasts: 511 nCPM
  • oocytes: 497 nCPM
  • megakaryocyte progenitors: 338 nCPM
  • migrating cytotrophoblasts: 260 nCPM

Immune cell

  • T-reg: 8.2 nTPM
  • total PBMC: 3.2 nTPM
  • neutrophil: 2.1 nTPM
  • NK-cell: 2.1 nTPM
  • memory CD8 T-cell: 1.7 nTPM
  • memory B-cell: 0.9 nTPM

Brain region

  • thalamus: 3.6 nTPM
  • cerebellum: 2.1 nTPM
  • choroid plexus: 1.8 nTPM
  • pons: 1.7 nTPM
  • cerebral cortex: 1.4 nTPM
  • white matter: 1.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UBE2C.

Disease | ImmuneIEDB

Conditions an epitope on UBE2C was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.85
gnomAD pLI
0.11
gnomAD missense Z
0.5
DepMap mean gene effect
-0.71
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE2C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2C as an antibody target. Whether an autoantibody or antibody against UBE2C could matter depends on whether native UBE2C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2C is annotated at the cell surface, where native UBE2C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label UBE2C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UBE2C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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