Seroatlas · Human Serome Atlas

ANAPC7

Anaphase-promoting complex subunit 7

Also known as: APC7, APC7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UJX3
Gene
ANAPC7
Ensembl
ENSG00000196510
Chromosome
12
Canonical length
565 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Microtubules,Cytokinetic bridge,Mitotic spindle
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

Canonical amino-acid sequenceUniProt

565 residues, UniProt reviewed canonical sequence.

>Q9UJX3|ANAPC7
     1  MNVIDHVRDM AAAGLHSNVR LLSSLLLTMS NNNPELFSPP QKYQLLVYHA DSLFHDKEYR
    61  NAVSKYTMAL QQKKALSKTS KVRPSTGNSA STPQSQCLPS EIEVKYKMAE CYTMLKQDKD
   121  AIAILDGIPS RQRTPKINMM LANLYKKAGQ ERPSVTSYKE VLRQCPLALD AILGLLSLSV
   181  KGAEVASMTM NVIQTVPNLD WLSVWIKAYA FVHTGDNSRA ISTICSLEKK SLLRDNVDLL
   241  GSLADLYFRA GDNKNSVLKF EQAQMLDPYL IKGMDVYGYL LAREGRLEDV ENLGCRLFNI
   301  SDQHAEPWVV SGCHSFYSKR YSRALYLGAK AIQLNSNSVQ ALLLKGAALR NMGRVQEAII
   361  HFREAIRLAP CRLDCYEGLI ECYLASNSIR EAMVMANNVY KTLGANAQTL TLLATVCLED
   421  PVTQEKAKTL LDKALTQRPD YIKAVVKKAE LLSREQKYED GIALLRNALA NQSDCVLHRI
   481  LGDFLVAVNE YQEAMDQYSI ALSLDPNDQK SLEGMQKMEK EESPTDATQE EDVDDMEGSG
   541  EEGDLEGSDS EAAQWADQEQ WFGMQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANAPC7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 35 nTPM
  • skeletal muscle: 33 nTPM
  • testis: 29 nTPM
  • vagina: 24 nTPM
  • cervix: 24 nTPM
  • parathyroid gland: 23 nTPM

Single-cell type

  • esophageal suprabasal cells: 87 nCPM
  • oocytes: 74 nCPM
  • late primary spermatocytes: 70 nCPM
  • early primary spermatocytes: 67 nCPM
  • esophageal basal cells: 59 nCPM
  • esophageal apical cells: 53 nCPM

Immune cell

  • T-reg: 27 nTPM
  • NK-cell: 26 nTPM
  • MAIT T-cell: 23 nTPM
  • eosinophil: 22 nTPM
  • basophil: 22 nTPM
  • myeloid DC: 21 nTPM

Brain region

  • basal ganglia: 18 nTPM
  • cerebral cortex: 18 nTPM
  • hippocampal formation: 15 nTPM
  • hypothalamus: 15 nTPM
  • cerebellum: 15 nTPM
  • white matter: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ANAPC7.

Disease | AllUniProt

Conditions ANAPC7 is implicated in, by any mechanism.

  • Ferguson-Bonni neurodevelopmental syndrome (FERBON) MIM:619699

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 81 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Ferguson-Bonni neurodevelopmental syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.85
gnomAD missense Z
2.12
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANAPC7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANAPC7 as an antibody target. Whether an autoantibody or antibody against ANAPC7 could matter depends on whether native ANAPC7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANAPC7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANAPC7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANAPC7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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