Krueppel C2H2-type Zinc Finger
IPR050826
Definition
The Krueppel C2H2-type zinc-finger protein family is characterized by its involvement in transcriptional regulation. Members of this family typically contain C2H2-type zinc-finger domains, which are known for their role in DNA binding and gene expression modulation. Some proteins within the family may function as transcriptional repressors, potentially suppressing transcriptional activities mediated by specific signaling pathways, such as the MAPK pathway. Others may act as transcriptional activators, directly influencing the expression of genes like NPPA. Certain members are implicated in cellular processes like apoptosis, and may interact with proteins such as p53/TP53, BAX, and TRAF2 to mediate cell death pathways in response to DNA damage. Domains like the KRAB and SCAN domains contribute to the transcriptional repressor activity and enable dimerization, respectively, which further diversifies the regulatory roles of the family in gene expression.
23 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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