Seroatlas · Human Serome Atlas

ZNF383

Zinc finger protein 383

Also known as: FLJ35863, Zfp383, ZN383_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NA42
Gene: ZNF383
Ensembl: ENSG00000188283
Chromosome: 19
Canonical length: 475 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

The protein encoded by this gene is a KRAB-related zinc finger protein that inhibits the transcription of some MAPK signaling pathway genes. The repressor activity resides in the KRAB domain of the encoded protein. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

475 residues, UniProt reviewed canonical sequence.

>Q8NA42|ZNF383
     1  MAEGSVMFSD VSIDFSQEEW DCLDPVQRDL YRDVMLENYG NLVSMGLYTP KPQVISLLEQ
    61  GKEPWMVGRE LTRGLCSDLE SMCETKLLSL KKEVYEIELC QREIMGLTKH GLEYSSFGDV
   121  LEYRSHLAKQ LGYPNGHFSQ EIFTPEYMPT FIQQTFLTLH QIINNEDRPY ECKKCGKAFS
   181  QNSQFIQHQR IHIGEKSYEC KECGKFFSCG SHVTRHLKIH TGEKPFECKE CGKAFSCSSY
   241  LSQHQRIHTG KKPYECKECG KAFSYCSNLI DHQRIHTGEK PYECKVCGKA FTKSSQLFQH
   301  ARIHTGEKPY ECKECGKAFT QSSKLVQHQR IHTGEKPYEC KECGKAFSSG SALTNHQRIH
   361  TGEKPYDCKE CGKAFTQSSQ LRQHQRIHAG EKPFECLECG KAFTQNSQLF QHQRIHTDEK
   421  PYECNECGKA FNKCSNLTRH LRIHTGEKPY NCKECGKAFS SGSDLIRHQG IHTNK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF383 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 8.8 nTPM

Expression across tissuesHPA

Tissue

tongue: 8.8 nTPM
skeletal muscle: 7.1 nTPM
tonsil: 5.9 nTPM
lymph node: 5.8 nTPM
thymus: 5.4 nTPM
ovary: 5.1 nTPM

Single-cell type

myonuclei: 74 nCPM
cardiomyocytes: 61 nCPM
distal convoluted tubule cells: 31 nCPM
medullary thymic epithelial cells: 29 nCPM
retinal horizontal cells: 28 nCPM
thymic myoid cells: 26 nCPM

Immune cell

naive B-cell: 11 nTPM
naive CD4 T-cell: 8.8 nTPM
MAIT T-cell: 8.5 nTPM
memory B-cell: 8.3 nTPM
memory CD8 T-cell: 7.4 nTPM
naive CD8 T-cell: 7.1 nTPM

Brain region

cerebellum: 29 nTPM
white matter: 26 nTPM
basal ganglia: 21 nTPM
pons: 20 nTPM
thalamus: 20 nTPM
medulla oblongata: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: 1.05
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF383 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF383 as an antibody target. Whether an autoantibody or antibody against ZNF383 could matter depends on whether native ZNF383 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF383 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF383 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...