Seroatlas · Human Serome Atlas

ZNF655

Zinc finger protein 655

Also known as: VIK, VIK-1, ZN655_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N720
Gene: ZNF655
Ensembl: ENSG00000197343
Chromosome: 7
Canonical length: 491 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

This gene encodes a zinc finger protein. The zinc finger proteins are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

491 residues, UniProt reviewed canonical sequence.

>Q8N720|ZNF655
     1  MEEIPAQEAA GSPRVQFQSL ETQSECLSPE PQFVQDTDME QGLTGDGETR EENKLLIPKQ
    61  KISEEVHSYK VRVGRLKHDI TQVPETREVY KSEDRLERLQ EILRKFLYLE REFRQITISK
   121  ETFTSEKNNE CHEPEKSFSL DSTIDADQRV LRIQNTDDND KYDMSFNQNS ASGKHEHLNL
   181  TEDFQSSECK ESLMDLSHLN KWESIPNTEK SYKCDVCGKI FHQSSALTRH QRIHTREKPY
   241  KCKECEKSFS QSSSLSRHKR IHTREKPYKC EASDKSCEAS DKSCSPSSGI IQHKKIHTRA
   301  KSYKCSSCER VFSRSVHLTQ HQKIHKEMPC KCTVCGSDFC HTSYLLEHQR VHHEEKAYEY
   361  DEYGLAYIKQ QGIHFREKPY TCSECGKDFR LNSHLIQHQR IHTGEKAHEC NECGKAFSQT
   421  SCLIQHHKMH RKEKSYECNE YEGSFSHSSD LILQQEVLTR QKAFDCDVWE KNSSQRAHLV
   481  QHQSIHTKEN S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF655 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

esophagus: 26 nTPM
pancreas: 22 nTPM
thymus: 21 nTPM
skin: 19 nTPM
lymph node: 18 nTPM
urinary bladder: 18 nTPM

Single-cell type

cardiomyocytes: 18 nCPM
epicardial cells: 9.1 nCPM
esophageal apical cells: 7.2 nCPM
basal prostatic cells: 5.1 nCPM
medullary thymic epithelial cells: 4.8 nCPM
retinal pigment epithelial cells: 4.3 nCPM

Immune cell

basophil: 148 nTPM
eosinophil: 75 nTPM
T-reg: 62 nTPM
memory CD8 T-cell: 56 nTPM
non-classical monocyte: 56 nTPM
total PBMC: 56 nTPM

Brain region

white matter: 34 nTPM
cerebellum: 33 nTPM
cerebral cortex: 31 nTPM
amygdala: 30 nTPM
pons: 28 nTPM
thalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0.15
gnomAD missense Z: 0.66
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF655 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF655 as an antibody target. Whether an autoantibody or antibody against ZNF655 could matter depends on whether native ZNF655 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF655 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF655 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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