Seroatlas · Human Serome Atlas

ZNF33B

Zinc finger protein 33B

Also known as: KOX2, KOX31, ZN33B_HUMAN, ZNF11B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q06732
Gene
ZNF33B
Ensembl
ENSG00000196693
Chromosome
10
Canonical length
778 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoli fibrillar center,Endoplasmic reticulum,Vesicles

OverviewNCBI Gene

This gene encodes a member of the zinc finger family of proteins. This gene shows decreased expression in cumulus cells derived from patients undergoing controlled ovarian stimulation. This gene is present in a gene cluster with several related zinc finger genes in the pericentromeric region of chromosome 10. Pseudogenes have been identified on chromosomes 7 and 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Canonical amino-acid sequenceUniProt

778 residues, UniProt reviewed canonical sequence.

>Q06732|ZNF33B
     1  MNKVDQKFQG SVSFKDVTVG FTQEEWQHLD PSQRALYRDV MLENYSNLVS VGYCAHKPEV
    61  IFRLEQGEEP WRLEEEFPSQ SFPEVWTADH LKERSQENQS KHLWEVVFIN NEMLTKEQGN
   121  VIGIPFNMDV SSFPSRKMFC QYDSRGMSFN TVSELVISKI NYLGKKSDEF NACGKLLLNI
   181  KHDETHTREK NEVLKNRNTL SHRENTLQHE KIQTLDHNFE YSICQETLLE KAVFNTRKRE
   241  NAEENNCDYN EFGRTFCDSS SLLFHQIPPS KDSHYEFSDC EKFLCVKSTL SKHDGVPVKH
   301  YDCGESGNNF RRKLCLSQLQ KGDKGEKHFE CNECGKAFWE KSHLTRHQRV HTGEKHFQCN
   361  QCGKTFWEKS NLTKHQRSHT GEKPFECNEC GKAFSHKSAL TLHQRTHTGE KPYQCNACGK
   421  TFYQKSDLTK HQRTHTGQKP YECYECGKSF CMNSHLTVHQ RTHTGEKPFE CLECGKSFCQ
   481  KSHLTQHQRT HIGDKPYECN ACGKTFYHKS VLTRHQIIHT GLKPYECYEC GKTFCLKSDL
   541  TIHQRTHTGE KPFACPECGK FFSHKSTLSQ HYRTHTGEKP YECHECGKIF YNKSYLTKHN
   601  RTHTGEKPYE CNECGKTFCQ KSQLTQHQRI HIGEKPYECN ECGKAFCHKS ALIVHQRTHT
   661  QEKPYKCNEC GKSFCVKSGL ILHERKHTGE KPYECNECGK SFSHKSSLTV HHRAHTGEKS
   721  CQCNECGKIF YRKSDLAKHQ RSHTGEKPYE CNTCRKTFSQ KSNLIVHQRT HIGEKPYE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF33B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 32 nTPM
  • breast: 19 nTPM
  • ovary: 18 nTPM
  • fallopian tube: 18 nTPM
  • kidney: 17 nTPM
  • salivary gland: 17 nTPM

Single-cell type

  • thyrotrophs: 176 nCPM
  • proximal tubule cells: 161 nCPM
  • pancreatic acinar cells: 126 nCPM
  • distal convoluted tubule cells: 124 nCPM
  • lactotrophs: 119 nCPM
  • renal collecting duct principal cells: 119 nCPM

Immune cell

  • memory B-cell: 20 nTPM
  • basophil: 20 nTPM
  • naive CD4 T-cell: 20 nTPM
  • memory CD4 T-cell: 16 nTPM
  • naive B-cell: 16 nTPM
  • MAIT T-cell: 15 nTPM

Brain region

  • cerebellum: 25 nTPM
  • choroid plexus: 24 nTPM
  • hypothalamus: 18 nTPM
  • pons: 15 nTPM
  • cerebral cortex: 14 nTPM
  • basal ganglia: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.78
gnomAD pLI
0
gnomAD missense Z
-0.22
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF33B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF33B as an antibody target. Whether an autoantibody or antibody against ZNF33B could matter depends on whether native ZNF33B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF33B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF33B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF33B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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