Seroatlas · Human Serome Atlas

ZNF134

Zinc finger protein 134

Also known as: pHZ-15, ZN134_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P52741
Gene: ZNF134
Ensembl: ENSG00000213762
Chromosome: 19
Canonical length: 427 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

427 residues, UniProt reviewed canonical sequence.

>P52741|ZNF134
     1  MTLVTAGGAW TGPGCWHEVK DEESSSEQSI SIAVSHVNTS KAGLPAQTAL PCDICGPILK
    61  DILHLDEHQG THHGLKLHTC GACGRQFWFS ANLHQYQKCY SIEQPLRRDK SEASIVKNCT
   121  VSKEPHPSEK PFTCKEEQKN FQATLGGCQQ KAIHSKRKTH RSTESGDAFH GEQMHYKCSE
   181  CGKAFSRKDT LVQHQRIHSG EKPYECSECG KAFSRKATLV QHQRIHTGER PYECSECGKT
   241  FSRKDNLTQH KRIHTGEMPY KCNECGKYFS HHSNLIVHQR VHNGARPYKC SDCGKVFRHK
   301  STLVQHESIH TGENPYDCSD CGKSFGHKYT LIKHQRIHTE SKPFECIECG KFFSRSSDYI
   361  AHQRVHTGER PFVCSKCGKD FIRTSHLVRH QRVHTGERPY ECSECGKAYS LSSHLNRHQK
   421  VHTAGRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF134 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 12 nTPM
parathyroid gland: 11 nTPM
thymus: 10 nTPM
cerebellum: 9.9 nTPM
retina: 9.8 nTPM
tonsil: 8 nTPM

Single-cell type

syncytiotrophoblasts: 20 nCPM
esophageal apical cells: 19 nCPM
corticotrophs: 19 nCPM
undifferentiated spermatogonia: 18 nCPM
differentiating spermatogonia: 18 nCPM
lactotrophs: 18 nCPM

Immune cell

NK-cell: 12 nTPM
memory B-cell: 9.6 nTPM
MAIT T-cell: 8.3 nTPM
naive B-cell: 8.3 nTPM
naive CD4 T-cell: 7.5 nTPM
naive CD8 T-cell: 7.5 nTPM

Brain region

cerebellum: 23 nTPM
hypothalamus: 17 nTPM
cerebral cortex: 16 nTPM
basal ganglia: 15 nTPM
hippocampal formation: 15 nTPM
amygdala: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
gnomAD missense Z: -0.45
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF134 as an antibody target. Whether an autoantibody or antibody against ZNF134 could matter depends on whether native ZNF134 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF134 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF134 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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