Seroatlas · Human Serome Atlas

ZNF559

Zinc finger protein 559

Also known as: MGC13105, ZN559_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BR84
Gene: ZNF559
Ensembl: ENSG00000188321
Chromosome: 19
Canonical length: 538 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

538 residues, UniProt reviewed canonical sequence.

>Q9BR84|ZNF559
     1  MVAGWLTNYS QDSVTFEDVA VDFTQEEWTL LDQTQRNLYR DVMLENYKNL VAVDWESHIN
    61  TKWSAPQQNF LQGKTSSVVE MERNHFGEEL FDFNQCEKAL SEHSCLKTHR RTYFRKKTCE
   121  CNQCEKAFRK PSIFTLHKKT DIGEELPNCN QCETAFSQHL HLVCKKTSQN LHLVCKKTHT
   181  QEKPYKCSDC EKGLPSSSHL RECVRIYGGE RPYTHKEYVE TFSHSTALFV HMQTQDGEKF
   241  YECKACGKPF TESSYLTQHL RTHSRVLPIE HKKFGKAFAF SPDLAKHIRL RTRGKHYVCN
   301  ECGKEFTCFS KLNIHIRVHT GEKPYECNKC GKAFTDSSGL IKHRRTHTGE KPYECKECGK
   361  AFANSSHLTV HMRTHTGEKP YQCKECGKAF INSSSFKSHM QTHPGVKPYD CQQCGKAFIR
   421  SSFLIRHLRS HSAERPFECE ECGKAFRYSS HLSQHKRIHT GERPYKCQKC GQAFSISSGL
   481  TVHMRTHTGE RPFECQECGK AFTRSTYLIR HLRSHSVEKP YKECGQTFSN SSCLTECV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF559 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

ovary: 32 nTPM
pituitary gland: 26 nTPM
cervix: 24 nTPM
fallopian tube: 23 nTPM
spleen: 21 nTPM
endometrium: 21 nTPM

Single-cell type

bergmann glia: 65 nCPM
choroid plexus epithelial cells: 54 nCPM
oligodendrocytes: 48 nCPM
oligodendrocyte progenitor cells: 47 nCPM
microglia: 47 nCPM
other brain neurons: 46 nCPM

Immune cell

basophil: 41 nTPM
naive CD4 T-cell: 21 nTPM
NK-cell: 21 nTPM
memory B-cell: 17 nTPM
naive CD8 T-cell: 17 nTPM
naive B-cell: 17 nTPM

Brain region

cerebellum: 43 nTPM
white matter: 41 nTPM
choroid plexus: 40 nTPM
hypothalamus: 31 nTPM
basal ganglia: 30 nTPM
thalamus: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.82
gnomAD pLI: 0
gnomAD missense Z: -1.05
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF559 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF559 as an antibody target. Whether an autoantibody or antibody against ZNF559 could matter depends on whether native ZNF559 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF559 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF559 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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