Seroatlas · Human Serome Atlas

ZNF44

Zinc finger protein 44

Also known as: KOX7, ZNF44_HUMAN, ZNF504, ZNF55, ZNF58

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P15621
Gene: ZNF44
Ensembl: ENSG00000197857
Chromosome: 19
Canonical length: 663 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Microtubules,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

663 residues, UniProt reviewed canonical sequence.

>P15621|ZNF44
     1  MALCYGTFWG YPKMLEAANL MEGLVDIGPW VTLPRGQPEV LEWGLPKDQD SVAFEDVAVN
    61  FTHEEWALLG PSQKNLYRDV MRETIRNLNC IGMKWENQNI DDQHQNLRRN PRCDVVERFG
   121  KSKDGSQCGE TLSQIRNSIV NKNTPARVDA CGSSVNGEVI MGHSSLNCYI RVDTGHKHRE
   181  CHEYAEKSYT HKQCGKGLSY RHSFQTCERP HTGKKPYDCK ECGKTFSSPG NLRRHMVVKG
   241  GDGPYKCELC GKAFFWPSLL RMHERTHTGE KPYECKQCSK AFPVYSSYLR HEKIHTGEKP
   301  YECKQCSKAF PDYSSYLRHE RTHTGEKPYK CKQCGKAFSV SGSLRVHERI HTGEKPYTCK
   361  QCGKAFCHLG SFQRHMIMHS GDGPHKCKIC GKGFDFPGSA RIHEGTHTLE KPYECKQCGK
   421  LLSHRSSFRR HMMAHTGDGP HKCTVCGKAF DSPSVFQRHE RTHTGEKPYE CKQCGKAFRT
   481  SSSLRKHETT HTGEQPYKCK CGKAFSDLFS FQSHETTHSE EEPYECKECG KAFSSFKYFC
   541  RHERTHSEEK SYECQICGKA FSRFSYLKTH ERTHTAEKPY ECKQCRKAFF WPSFLLRHER
   601  THTGERPYEC KHCGKAFSRS SFCREHERTH TGEKPYECKE CGKAFSSLSS FNRHKRTHWK
   661  DIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF44 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

retina: 16 nTPM
parathyroid gland: 11 nTPM
liver: 10 nTPM
thyroid gland: 10 nTPM
skin: 9.9 nTPM
bone marrow: 9.7 nTPM

Single-cell type

early spermatids: 232 nCPM
distal convoluted tubule cells: 188 nCPM
renal connecting tubule cells: 179 nCPM
myonuclei: 158 nCPM
cardiomyocytes: 153 nCPM
podocytes: 151 nCPM

Immune cell

eosinophil: 16 nTPM
basophil: 13 nTPM
NK-cell: 12 nTPM
naive CD4 T-cell: 9.3 nTPM
naive CD8 T-cell: 9.1 nTPM
MAIT T-cell: 8.8 nTPM

Brain region

cerebellum: 21 nTPM
white matter: 18 nTPM
choroid plexus: 16 nTPM
midbrain: 16 nTPM
medulla oblongata: 16 nTPM
basal ganglia: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: 0.56
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF44 as an antibody target. Whether an autoantibody or antibody against ZNF44 could matter depends on whether native ZNF44 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF44 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF44 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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