Seroatlas · Human Serome Atlas

ZNF189

Zinc finger protein 189

Also known as: ZN189_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75820
Gene: ZNF189
Ensembl: ENSG00000136870
Chromosome: 9
Canonical length: 626 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Intermediate filaments

OverviewNCBI Gene

Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 [PubMed 9653648]). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box (KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always present.[supplied by OMIM, May 2010]

Canonical amino-acid sequenceUniProt

626 residues, UniProt reviewed canonical sequence.

>O75820|ZNF189
     1  MASPSPPPES KGLLTFEDVA VFFTQEEWDY LDPAQRSLYK DVMMENYGNL VSLDVLNRDK
    61  DEEPTVKQEI EEIEEEVEPQ GVIVTRIKSE IDQDPMGRET FELVGRLDKQ RGIFLWEIPR
   121  ESLTQEQRMF RENTNIIRKR PNSEEKCHKC EECGKGFVRK AHFIQHQRVH TGEKPFQCNE
   181  CGKSFSRSSF VIEHQRIHTG ERPYECNYCG KTFSVSSTLI RHQRIHTGER PYQCNQCKQS
   241  FSQRRSLVKH QRIHTGEKPH KCSDCGKAFS WKSHLIEHQR THTGEKPYHC TKCKKSFSRN
   301  SLLVEHQRIH TGERPHKCGE CGKAFRLSTY LIQHQKIHTG EKPFLCIECG KSFSRSSFLI
   361  EHQRIHTGER PYQCKECGKS FSQLCNLTRH QRIHTGDKPH KCEECGKAFS RSSGLIQHQR
   421  IHTREKTYPY NETKESFDPN CSLVIQQEVY PKEKSYKCDE CGKTFSVSAH LVQHQRIHTG
   481  EKPYLCTVCG KSFSRSSFLI EHQRIHTGER PYLCRQCGKS FSQLCNLIRH QGVHTGNKPH
   541  KCDECGKAFS RNSGLIQHQR IHTGEKPYKC EKCDKSFSQQ RSLVNHQKIH AEVKTQETHE
   601  CDACGEAFNC RISLIQHQKL HTAWMQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF189 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 79 nTPM

Expression across tissuesHPA

Tissue

epididymis: 79 nTPM
spinal cord: 33 nTPM
pancreas: 29 nTPM
adipose tissue: 23 nTPM
gallbladder: 22 nTPM
hippocampal formation: 22 nTPM

Single-cell type

epididymal principal cells: 158 nCPM
somatotrophs: 122 nCPM
pancreatic acinar cells: 120 nCPM
oligodendrocytes: 117 nCPM
cardiomyocytes: 106 nCPM
corticotrophs: 97 nCPM

Immune cell

memory CD8 T-cell: 1.5 nTPM
eosinophil: 1.4 nTPM
naive CD4 T-cell: 1.4 nTPM
NK-cell: 1.3 nTPM
memory CD4 T-cell: 1.2 nTPM
naive CD8 T-cell: 1.2 nTPM

Brain region

hippocampal formation: 57 nTPM
white matter: 53 nTPM
cerebral cortex: 48 nTPM
basal ganglia: 40 nTPM
medulla oblongata: 36 nTPM
cerebellum: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0
gnomAD missense Z: 0.45
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF189 as an antibody target. Whether an autoantibody or antibody against ZNF189 could matter depends on whether native ZNF189 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF189 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF189 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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