ZNF30
Zinc finger protein 30
Also known as: DKFZp686N19164, FLJ20562, KOX28, ZNF30_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P17039
- Gene
- ZNF30
- Ensembl
- ENSG00000168661
- Chromosome
- 19
- Canonical length
- 623 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
623 residues, UniProt reviewed canonical sequence.
>P17039|ZNF30
1 MAHKYVGLQY HGSVTFEDVA IAFSQQEWES LDSSQRGLYR DVMLENYRNL VSMGHSRSKP
61 HVIALLEQWK EPEVTVRKDG RRWCTDLQLE DDTIGCKEMP TSENCPSFAL HQKISRQKPR
121 ECQEYGKTLC QDSKPVQHER IHSSEKPNRC KECGKNFSNG HQLTIHQRLH VGEKPYKYEK
181 CGKAFISGSA FVKHGRIHTG EKPLKCKQCG KTISGSYQLT VHKSIHTGKK PYECGECGKA
241 FLVYGKLTRH QSTHTGEKPF GCEECGKAFS TFSYLVQHQR IHTSEKPYEC KECGKAFSTS
301 SPLAKHQRIH TGEKPYECKE CGKSFTVYGQ LTRHQSIHTG EKPFECKECG KAFRLSSFLH
361 AHQRIHAEIK PYGCKECGRT FSRASYLVQH GRLHTGEKPY ECKECGKAFS TGSYLVQHQR
421 IHTGEKPYEC KECGKAFISR HQLTVHQRVH TGEKPYECKE CGKAFRVHVH LTQHRKIHTD
481 VKPYECKECG KTFSRASYLV QHSRIHTGKK PYECKECGKA FSSGSYLVQH QRIHTGEKPY
541 ECNKCGKAFT VYGQLIGHQS VHTGEKPFEC KECGKAFRLN SFLTEHQRVH TGEKPFKCKK
601 CGKTFRYSSA LKVHLRKHMS VIPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.42
- Highest tissue expression
- 14 nTPM
Expression across tissuesHPA
Tissue
- retina: 14 nTPM
- cerebellum: 13 nTPM
- basal ganglia: 4.5 nTPM
- cerebral cortex: 3.9 nTPM
- hippocampal formation: 3.6 nTPM
- hypothalamus: 3.5 nTPM
Single-cell type
- rod photoreceptor cells: 57 nCPM
- cone photoreceptor cells: 46 nCPM
- bergmann glia: 27 nCPM
- myonuclei: 26 nCPM
- retinal bipolar cells: 24 nCPM
- brain inhibitory neurons: 22 nCPM
Immune cell
- naive CD8 T-cell: 4.9 nTPM
- NK-cell: 4.8 nTPM
- naive CD4 T-cell: 4.7 nTPM
- gdT-cell: 3.1 nTPM
- MAIT T-cell: 3.1 nTPM
- T-reg: 2.7 nTPM
Brain region
- cerebellum: 14 nTPM
- white matter: 9.3 nTPM
- cerebral cortex: 8.9 nTPM
- basal ganglia: 8.8 nTPM
- pons: 7.5 nTPM
- amygdala: 7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.76
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.26
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF30 as an antibody target. Whether an autoantibody or antibody against ZNF30 could matter depends on whether native ZNF30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF30 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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