Seroatlas · Human Serome Atlas

ZNF711

Zinc finger protein 711

Also known as: CMPX1, dJ75N13.1, MRX65, MRX97, Zfp711, ZN711_HUMAN, ZNF4, ZNF5, ZNF6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y462
Gene: ZNF711
Ensembl: ENSG00000147180
Chromosome: X
Canonical length: 761 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a zinc finger protein of unknown function. It bears similarity to a zinc finger protein which acts as a transcriptional activator. This gene lies in a region of the X chromosome which has been associated with cognitive disability. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

761 residues, UniProt reviewed canonical sequence.

>Q9Y462|ZNF711
     1  MDSGGGSLGL HTPDSRMAHT MIMQDFVAGM AGTAHIDGDH IVVSVPEAVL VSDVVTDDGI
    61  TLDHGLAAEV VHGPDIITET DVVTEGVIVP EAVLEADVAI EEDLEEDDGD HILTSELITE
   121  TVRVPEQVFV ADLVTGPNGH LEHVVQDCVS GVDSPTMVSE EVLVTNSDTE TVIQAAGGVP
   181  GSTVTIKTED DDDDDVKSTS EDYLMISLDD VGEKLEHMGN TPLKIGSDGS QEDAKEDGFG
   241  SEVIKVYIFK AEAEDDVEIG GTEIVTESEY TSGHSVAGVL DQSRMQREKM VYMAVKDSSQ
   301  EEDDIRDERR VSRRYEDCQA SGNTLDSALE SRSSTAAQYL QICDGINTNK VLKQKAKKRR
   361  RGETRQWQTA VIIGPDGQPL TVYPCHICTK KFKSRGFLKR HMKNHPDHLM RKKYQCTDCD
   421  FTTNKKVSFH NHLESHKLIN KVDKTHEFTE YTRRYREASP LSSNKLILRD KEPKMHKCKY
   481  CDYETAEQGL LNRHLLAVHS KNFPHVCVEC GKGFRHPSEL KKHMRTHTGE KPYQCQYCIF
   541  RCADQSNLKT HIKSKHGNNL PYKCEHCPQA FGDERELQRH LDLFQGHKTH QCPHCDHKST
   601  NSSDLKRHII SVHTKDFPHK CEVCDKGFHR PSELKKHSDI HKGRKIHQCR HCDFKTSDPF
   661  ILSGHILSVH TKDQPLKCKR CKRGFRQQNE LKKHMKTHTG RKIYQCEYCE YSTTDASGFK
   721  RHVISIHTKD YPHRCEFCKK GFRRPSEKNQ HIMRHHKEAL M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF711 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

testis: 35 nTPM
cerebral cortex: 18 nTPM
thymus: 15 nTPM
adrenal gland: 14 nTPM
skin: 12 nTPM
cerebellum: 11 nTPM

Single-cell type

sertoli cells: 452 nCPM
lactotrophs: 88 nCPM
hematopoietic stem cells: 77 nCPM
megakaryocyte-erythroid progenitors: 64 nCPM
thymocytes: 64 nCPM
oligodendrocyte progenitor cells: 58 nCPM

Immune cell

naive B-cell: 1.3 nTPM
memory B-cell: 0.7 nTPM
naive CD4 T-cell: 0.3 nTPM
naive CD8 T-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM

Brain region

basal ganglia: 18 nTPM
hypothalamus: 17 nTPM
cerebral cortex: 17 nTPM
cerebellum: 15 nTPM
spinal cord: 15 nTPM
midbrain: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZNF711.

Disease | AllUniProt

Conditions ZNF711 is implicated in, by any mechanism.

Intellectual developmental disorder, X-linked 97 (XLID97) MIM:300803

Disease | GeneticClinVar

16 pathogenic / likely-pathogenic of 287 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual disability, X-linked 97
Inborn genetic diseases
Intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.31
gnomAD pLI: 0.98
gnomAD missense Z: 2.4
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF711 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PHF8

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF711 as an antibody target. Whether an autoantibody or antibody against ZNF711 could matter depends on whether native ZNF711 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF711 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF711 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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