Seroatlas · Human Serome Atlas

ZNF260

Zinc finger protein 260

Also known as: ozrf1, Zfp260, ZN260_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q3ZCT1
Gene
ZNF260
Ensembl
ENSG00000254004
Chromosome
19
Canonical length
412 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

412 residues, UniProt reviewed canonical sequence.

>Q3ZCT1|ZNF260
     1  MIGMLESLQH ESDLLQHDQI HTGEKPYECN ECRKTFSLKQ NLVEHKKMHT GEKSHECTEC
    61  GKVCSRVSSL TLHLRSHTGK KAYKCNKCGK AFSQKENFLS HQKHHTGEKP YECEKVSIQM
   121  PTIIRHQKNH TGTKPYACKE CGKAFNGKAY LTEHEKIHTG EKPFECNQCG RAFSQKQYLI
   181  KHQNIHTGKK PFKCSECGKA FSQKENLIIH QRIHTGEKPY ECKGCGKAFI QKSSLIRHQR
   241  SHTGEKPYTC KECGKAFSGK SNLTEHEKIH IGEKPYKCNE CGTIFRQKQY LIKHHNIHTG
   301  EKPYECNKCG KAFSRITSLI VHVRIHTGDK PYECKVCGKA FCQSSSLTVH MRSHTGEKPY
   361  GCNECGKAFS QFSTLALHMR IHTGEKPYQC SECGKAFSQK SHHIRHQRIH TH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF260 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 11 nTPM
  • thyroid gland: 9.1 nTPM
  • ovary: 8.5 nTPM
  • retina: 8.2 nTPM
  • breast: 7.4 nTPM
  • thymus: 7.1 nTPM

Single-cell type

  • tuft cells: 46 nCPM
  • suprabasal keratinocytes: 45 nCPM
  • urothelial cells: 36 nCPM
  • esophageal apical cells: 36 nCPM
  • breast secretory cells: 34 nCPM
  • breast hormone-responsive cells: 34 nCPM

Immune cell

  • basophil: 4.5 nTPM
  • naive CD4 T-cell: 3.1 nTPM
  • naive B-cell: 2.9 nTPM
  • memory B-cell: 2.4 nTPM
  • naive CD8 T-cell: 2.4 nTPM
  • memory CD4 T-cell: 2.3 nTPM

Brain region

  • white matter: 14 nTPM
  • thalamus: 12 nTPM
  • hypothalamus: 12 nTPM
  • midbrain: 12 nTPM
  • basal ganglia: 12 nTPM
  • cerebellum: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.23
gnomAD pLI
0
gnomAD missense Z
0.61
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF260 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF260 as an antibody target. Whether an autoantibody or antibody against ZNF260 could matter depends on whether native ZNF260 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF260 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF260 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF260. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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