Seroatlas · Human Serome Atlas

ZNF311

Zinc finger protein 311

Also known as: ZN311_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5JNZ3
Gene
ZNF311
Ensembl
ENSG00000197935
Chromosome
6
Canonical length
666 aa
Protein class
Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

666 residues, UniProt reviewed canonical sequence.

>Q5JNZ3|ZNF311
     1  MQEVVLLDES SGPPSQLLWT RQDTQLPQES ALLPAPYPAF TKDGSQGNLP QADITLMSQA
    61  QESVTFEDVA VNFTNREWQC LTYAQRHLYK DVMLENYGNM VSLGFPFPKP PLISHLEREV
   121  DPCVQDPQDR ESLSCSYPVS ADKMWPENEK ASSQQEIFEN GEAYWMKFNS LLKVDSRDPK
   181  VREVCVQDVK LENQWETSIR EKLREEKEGS EEVTCKKGKN QKVLSKNLNP NSKHSQCNKV
   241  LIAQKLHECA RCGKNFSWHS DLILHEQIHS GEKPHVCNEC GKAFKTRNQL SMHRIIHTGE
   301  KPFNCTQCGK AFNSRSALCR HKKTHSGEKP HECRDCGKAF KTRNRLCMHQ LIHTGEKPYK
   361  CNCCGKAFQF KHSLTIHGRI HTGEKPYECE ECGKAFSGSS DLTKHIRIHT GERPYECSKC
   421  GRAFSRSSDL SKHKRIHTRE KHYGCPQCGK DFSIKAELTK HRRIHTEEKR YRCEECGKAF
   481  RHNCKRRAHE REHTGEKPYQ CRDCGKTFQD KHCLTIHQRI HTGEKPYKCL ECGKAFSGKS
   541  NLTNHRRIHT GEKPHKCEVC GMAFHHSSVL RQHKRIHTGE KPYTCSECGT SFRQGSALIG
   601  HKRVHTGEKP YECEECGKAF RVSSNLTGHK KRKHQVWSTH ELDGSRKSLS PVTVSQTSVV
   661  SILTSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF311 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
2.4 nTPM

Expression across tissuesHPA

Tissue

  • testis: 2.4 nTPM
  • ovary: 1.1 nTPM
  • thyroid gland: 1.1 nTPM
  • prostate: 1 nTPM
  • fallopian tube: 0.9 nTPM
  • cervix: 0.8 nTPM

Single-cell type

  • ependymal cells: 5.7 nCPM
  • bergmann glia: 5.5 nCPM
  • melanocytes: 4.1 nCPM
  • paneth cells: 3.9 nCPM
  • papillary tip epithelial cells: 3.6 nCPM
  • renal collecting duct principal cells: 3.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 0.5 nTPM
  • white matter: 0.5 nTPM
  • hippocampal formation: 0.3 nTPM
  • cerebral cortex: 0.2 nTPM
  • pons: 0.2 nTPM
  • spinal cord: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.91
gnomAD pLI
0
gnomAD missense Z
0.83
DepMap mean gene effect
-0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF311 as an antibody target. Whether an autoantibody or antibody against ZNF311 could matter depends on whether native ZNF311 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF311 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF311 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF311. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...