Seroatlas · Human Serome Atlas

ZNF789

Zinc finger protein 789

Also known as: ZN789_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5FWF6
Gene: ZNF789
Ensembl: ENSG00000198556
Chromosome: 7
Canonical length: 425 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

425 residues, UniProt reviewed canonical sequence.

>Q5FWF6|ZNF789
     1  MFPPARGKEL LSFEDVAMYF TREEWGHLNW GQKDLYRDVM LENYRNMVLL GFQFPKPEMI
    61  CQLENWDEQW ILDLPRTGNR KASGSACPGS EARHKMKKLT PKQKFSEDLE SYKISVVMQE
   121  SAEKLSEKLH KCKEFVDSCR LTFPTSGDEY SRGFLQNLNL IQDQNAQTRW KQGRYDEDGK
   181  PFNQRSLLLG HERILTRAKS YECSECGKVI RRKAWFDQHQ RIHFLENPFE CKVCGQAFRQ
   241  RSALTVHKQC HLQNKPYRCH DCGKCFRQLA YLVEHKRIHT KEKPYKCSKC EKTFSQNSTL
   301  IRHQVIHSGE KRHKCLECGK AFGRHSTLLC HQQIHSKPNT HKCSECGQSF GRNVDLIQHQ
   361  RIHTKEEFFQ CGECGKTFSF KRNLFRHQVI HTGSQPYQCV ICGKSFKWHT SFIKHQGTHK
   421  GQIST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF789 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

prostate: 16 nTPM
cerebellum: 15 nTPM
testis: 13 nTPM
pituitary gland: 12 nTPM
retina: 11 nTPM
spleen: 11 nTPM

Single-cell type

cardiomyocytes: 132 nCPM
epicardial cells: 116 nCPM
fibro-adipogenic progenitors: 61 nCPM
adipocytes: 58 nCPM
neutrophils: 56 nCPM
pdcs: 55 nCPM

Immune cell

plasmacytoid DC: 14 nTPM
naive CD4 T-cell: 6.1 nTPM
myeloid DC: 5.2 nTPM
T-reg: 5.1 nTPM
NK-cell: 4.2 nTPM
naive CD8 T-cell: 3.7 nTPM

Brain region

cerebellum: 11 nTPM
white matter: 7.4 nTPM
cerebral cortex: 6.7 nTPM
midbrain: 6.7 nTPM
hypothalamus: 6.6 nTPM
pons: 6.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: 0.48
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF789 as an antibody target. Whether an autoantibody or antibody against ZNF789 could matter depends on whether native ZNF789 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF789 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF789 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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