Seroatlas · Human Serome Atlas

ZNF726

Zinc finger protein 726

Also known as: ZN726_HUMAN, ZNF92P3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NNF4
Gene: ZNF726
Ensembl: ENSG00000213967
Chromosome: 19
Canonical length: 616 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

616 residues, UniProt reviewed canonical sequence.

>A6NNF4|ZNF726
     1  MGLLTFRDVA IEFSLEEWQC LDTAQKNLYR NVMLENYRNL AFLGIAVSKP DLIICLEKEK
    61  EPWNMKRDEM VDEPPGICPH FAQDIWPEQG VEDSFQKVIL RRFEKCGHEN LQLRKGCKSV
   121  DECKVHKEGY NGLNQCFTTT QGKASQCGKY LKVFYKFINL NRYKIRHTRK KPFKCKNCVK
   181  SFCMFSHKTQ HKSIYTTEKS YKCKECGKTF NWSSTLTNHK KTHTEEKPYK CEEYGKAFNQ
   241  SSNYTTHKVT HTGEKPYKCE ECGKAFSQSS TLTIHKRIHT GEKPCKCEEC GKAFSQPSAL
   301  TIHKRMHIGE KPYKCEECGK AFVWSSTLTR HKRLHSGEKP YKCEECAKAF SQFGHLTTHR
   361  IIHTGEKPYK CEECGKAFIW PSTLTKHKRI HTGEKPYKCE ECGKAFHRSS NLTKHKIIHT
   421  GEKPYKCEEC GKAFIWSSNL TEHKKIHTRE KPYKCEECSK AFSRSSALTT HKRMHTGEKP
   481  YKCEECGKAF SQSSTLTAHK IIHTGEKPYK CEECGKAFIL SSTLSKHKRI HTGEKPYKCE
   541  ECGKTFNQSS NLSTHKIIHT GEKPYKCEEC GKAFNRSSNL STHKIIHTGE KPYKCDECGK
   601  SFIWSSTLFK HKRIHT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF726 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 5.6 nTPM

Expression across tissuesHPA

Tissue

thymus: 5.6 nTPM
bone marrow: 5.5 nTPM
epididymis: 4.8 nTPM
skin: 4.5 nTPM
lymph node: 4 nTPM
breast: 3.9 nTPM

Single-cell type

epididymal principal cells: 28 nCPM
extravillous trophoblasts: 21 nCPM
migrating cytotrophoblasts: 17 nCPM
respiratory ionocytes: 15 nCPM
esophageal apical cells: 15 nCPM
cytotrophoblasts: 13 nCPM

Immune cell

basophil: 7.8 nTPM
NK-cell: 3.3 nTPM
T-reg: 1.2 nTPM
naive CD8 T-cell: 1.1 nTPM
plasmacytoid DC: 1.1 nTPM
memory CD4 T-cell: 1 nTPM

Brain region

cerebellum: 14 nTPM
hypothalamus: 14 nTPM
amygdala: 12 nTPM
white matter: 12 nTPM
basal ganglia: 11 nTPM
thalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0
gnomAD missense Z: -2.66
DepMap mean gene effect: -0.01
DepMap dependency class: none

OntologyGO

Biological processes

negative regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF726 as an antibody target. Whether an autoantibody or antibody against ZNF726 could matter depends on whether native ZNF726 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF726 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF726 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...