Seroatlas · Human Serome Atlas

ZNF23

Zinc finger protein 23

Also known as: KOX16, Zfp612, ZNF23_HUMAN, ZNF359, ZNF612

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P17027
Gene: ZNF23
Ensembl: ENSG00000167377
Chromosome: 16
Canonical length: 643 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Cytosol

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

643 residues, UniProt reviewed canonical sequence.

>P17027|ZNF23
     1  MLENYGNVAS LGFPLLKPAV ISQLEGGSEL GGSSPLAAGT GLQGLQTDIQ TDNDLTKEMY
    61  EGKENVSFEL QRDFSQETDF SEASLLEKQQ EVHSAGNIKK EKSNTIDGTV KDETSPVEEC
   121  FFSQSSNSYQ CHTITGEQPS GCTGLGKSIS FDTKLVKHEI INSEERPFKC EELVEPFRCD
   181  SQLIQHQENN TEEKPYQCSE CGKAFSINEK LIWHQRLHSG EKPFKCVECG KSFSYSSHYI
   241  THQTIHSGEK PYQCKMCGKA FSVNGSLSRH QRIHTGEKPY QCKECGNGFS CSSAYITHQR
   301  VHTGEKPYEC NDCGKAFNVN AKLIQHQRIH TGEKPYECNE CGKGFRCSSQ LRQHQSIHTG
   361  EKPYQCKECG KGFNNNTKLI QHQRIHTGEK PYECTECGKA FSVKGKLIQH QRIHTGEKPY
   421  ECNECGKAFR CNSQFRQHLR IHTGEKPYEC NECGKAFSVN GKLMRHQRIH TGEKPFECNE
   481  CGRCFTSKRN LLDHHRIHTG EKPYQCKECG KAFSINAKLT RHQRIHTGEK PFKCMECEKA
   541  FSCSSNYIVH QRIHTGEKPF QCKECGKAFH VNAHLIRHQR SHTGEKPFRC VECGKGFSFS
   601  SDYIIHQTVH TWKKPYMCSV CGKAFRFSFQ LSQHQSVHSE GKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 15 nTPM
retina: 15 nTPM
pituitary gland: 14 nTPM
cerebellum: 13 nTPM
hippocampal formation: 9.2 nTPM
hypothalamus: 8.7 nTPM

Single-cell type

ependymal cells: 43 nCPM
bergmann glia: 26 nCPM
choroid plexus epithelial cells: 26 nCPM
astrocytes: 18 nCPM
oligodendrocytes: 16 nCPM
oligodendrocyte progenitor cells: 15 nCPM

Immune cell

naive B-cell: 2.6 nTPM
NK-cell: 2.6 nTPM
memory CD8 T-cell: 2.1 nTPM
naive CD4 T-cell: 2.1 nTPM
plasmacytoid DC: 1.9 nTPM
gdT-cell: 1.8 nTPM

Brain region

white matter: 10 nTPM
choroid plexus: 8.5 nTPM
cerebellum: 8.3 nTPM
cerebral cortex: 8.3 nTPM
hypothalamus: 7.9 nTPM
basal ganglia: 7.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: 0.36
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF23 as an antibody target. Whether an autoantibody or antibody against ZNF23 could matter depends on whether native ZNF23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF23 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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