Seroatlas · Human Serome Atlas

ZNF778

Zinc finger protein 778

Also known as: FLJ31875, ZN778_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MU6
Gene: ZNF778
Ensembl: ENSG00000170100
Chromosome: 16
Canonical length: 729 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

The protein encoded by this gene is a member of the krueppel C2H2-type zinc-finger protein family, and it contains one KRAB domain and eighteen C2H2-type zinc fingers. This gene is a candidate gene for autism and variable cognitive impairment in the 16q24.3 microdeletion syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

729 residues, UniProt reviewed canonical sequence.

>Q96MU6|ZNF778
     1  MAAPDLAHGG HVSRDSVCLH EEQTQAAGMV AGWLINCYQD AVTFDDVAVD FTQEEWTLLD
    61  PSQRDLYRDV MLENYENLAS VEWRLKTKGP ALRQDRSWFR ASNETQTARS HNGGQLCDRT
   121  QCGEAFSEHS GLSTHVRTQN TGDSCVSNHY ERDFFIPCQK TLFKIGEQFS VLGQCGKAFS
   181  STPNVVSQQA CTRDRSLDYS SCGEVFLNQS YLQARAGSHN GEETWKWKPC GKALTHSMGC
   241  ATPVEMHAVR NPHVCRECGK AFRYTAYLTG RVQVHPGEKP CELEECGKAS PVSSSLTQHV
   301  RIHAAEKPCE CKECGKAFTG LSGLSKHVQT DPGQKPYECK DCGKACGGFY LLNEHGKTHT
   361  REKPFACVVC GKYFRNSSCL NNHVRIHTGI KPYTCSYCGK AFTVRCGLTR HVRTHTGEKP
   421  YTCKDCGKAF CTSSGLTEHV RTHTGEKPYE CKDCGKSFTV SSSLTEHARI HTGEKPYECK
   481  QCGKAFTGRS GLTKHMRTHT GEKPYECKDC GKAYNRVYLL NEHVKTHTEE KPFICTVCRK
   541  SFRNSSCLNK HIQIHTGIKP YECKDCGKTF TVSSSLTEHI RTHTGEKPYE CKVCGKAFTT
   601  SSHLIVHIRT HTGEKPYICK ECGKAFASSS HLIEHRRTHT GEKPYICNEC GKAFRASSHL
   661  HKHGRIHTGQ KPYKCKECGK AYNRFYLLKE HLKTYTEEQV FVCKDCGKSF KNSSCLNHHT
   721  QIHTDEKPF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF778 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 7.6 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 7.6 nTPM
testis: 4.8 nTPM
pancreas: 4.7 nTPM
tongue: 4 nTPM
retina: 3.6 nTPM
skeletal muscle: 3.5 nTPM

Single-cell type

platelets: 321 nCPM
late spermatids: 58 nCPM
retinal horizontal cells: 34 nCPM
hepatic stellate cells: 32 nCPM
early primary spermatocytes: 28 nCPM
undifferentiated spermatogonia: 24 nCPM

Immune cell

basophil: 11 nTPM
eosinophil: 3.2 nTPM
gdT-cell: 3 nTPM
non-classical monocyte: 2.1 nTPM
intermediate monocyte: 1.9 nTPM
naive CD8 T-cell: 1.9 nTPM

Brain region

pons: 14 nTPM
cerebellum: 12 nTPM
midbrain: 10 nTPM
cerebral cortex: 9.8 nTPM
thalamus: 9.7 nTPM
white matter: 9.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: -3.26
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF778 as an antibody target. Whether an autoantibody or antibody against ZNF778 could matter depends on whether native ZNF778 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF778 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF778 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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