Seroatlas · Human Serome Atlas

ZFP37

Zinc finger protein 37 homolog

Also known as: ZFP37_HUMAN, ZNF906

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y6Q3
Gene: ZFP37
Ensembl: ENSG00000136866
Chromosome: 9
Canonical length: 630 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a transcription factor that belongs to a large family of zinc finger proteins. A similar protein in mouse is thought to play a role in regulating the structures of the nucleolus and centromere in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

630 residues, UniProt reviewed canonical sequence.

>Q9Y6Q3|ZFP37
     1  MSVSSGVQIL TKPETVDRRR SAETTKEAGR PLEMAVSEPE ASAAEWKQLD PAQSNLYNDV
    61  MLENYCNQAS MGCQAPKPDM ISKLEKGEAP WLGKGKRPSQ GCPSKIARPK QKETDGKVQK
   121  DDDQLENIQK SQNKLLREVA VKKKTQAKKN GSDCGSLGKK NNLHKKHVPS KKRLLKFESC
   181  GKILKQNLDL PDHSRNCVKR KSDAAKEHKK SFNHSLSDTR KGKKQTGKKH EKLSSHSSSD
   241  KCNKTGKKHD KLCCHSSSHI KQDKIQTGEK HEKSPSLSSS TKHEKPQACV KPYECNQCGK
   301  VLSHKQGLID HQRVHTGEKP YECNECGIAF SQKSHLVVHQ RTHTGEKPYE CIQCGKAHGH
   361  KHALTDHLRI HTGEKPYECA ECGKTFRHSS NLIQHVRSHT GEKPYECKEC GKSFRYNSSL
   421  TEHVRTHTGE IPYECNECGK AFKYSSSLTK HMRIHTGEKP FECNECGKAF SKKSHLIIHQ
   481  RTHTKEKPYK CNECGKAFGH SSSLTYHMRT HTGESPFECN QCGKGFKQIE GLTQHQRVHT
   541  GEKPYECNEC GKAFSQKSHL IVHQRTHTGE KPYECNECEK AFNAKSQLVI HQRSHTGEKP
   601  YECNECGKTF KQNASLTKHV KTHSEDKSHE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFP37 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 6.3 nTPM

Expression across tissuesHPA

Tissue

ovary: 6.3 nTPM
retina: 5.9 nTPM
endometrium: 4.2 nTPM
cerebellum: 4 nTPM
pituitary gland: 3.5 nTPM
cerebral cortex: 3.4 nTPM

Single-cell type

lactotrophs: 39 nCPM
retinal bipolar cells: 38 nCPM
somatotrophs: 32 nCPM
retinal amacrine cells: 27 nCPM
oligodendrocyte progenitor cells: 26 nCPM
retinal pigment epithelial cells: 26 nCPM

Immune cell

T-reg: 2.4 nTPM
gdT-cell: 0.9 nTPM
memory B-cell: 0.9 nTPM
memory CD8 T-cell: 0.9 nTPM
naive CD8 T-cell: 0.9 nTPM
memory CD4 T-cell: 0.8 nTPM

Brain region

cerebellum: 11 nTPM
white matter: 10 nTPM
hypothalamus: 8.8 nTPM
basal ganglia: 8 nTPM
spinal cord: 7.3 nTPM
pons: 7.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.32
gnomAD pLI: 0
gnomAD missense Z: 0.35
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFP37 as an antibody target. Whether an autoantibody or antibody against ZFP37 could matter depends on whether native ZFP37 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFP37 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFP37 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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