Seroatlas · Human Serome Atlas

ZNF716

Zinc finger protein 716

Also known as: FLJ46189, ZN716_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NP11
Gene: ZNF716
Ensembl: ENSG00000182111
Chromosome: 7
Canonical length: 495 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

495 residues, UniProt reviewed canonical sequence.

>A6NP11|ZNF716
     1  MAKRPGPPGS REMGLLTFRD IAIEFSLAEW QCLDHAQQNL YRDVMLENYR NLVSLGIAVS
    61  KPDLITCLEQ NKEPQNIKRN EMVAKHPVTC SHFTQDLQSE QGIKDSLQKV ILRRYGKCGQ
   121  EDLQVKKCCK SVGECEVHKG GYNYVNQCLS ATQNKTFQTH KCVKVFGKFS NSNRHKTRHT
   181  GKKHFKCKND GKSFCMLSRL NQHQIIHTRE KSYKCEECGK SFNCSSTLTR HKRIHTGEKP
   241  YRCEECGKAF SWSASLTKHK RIHTGEKPYT CEERGKVFSR STLTNYKRIH TGEKPYTCEE
   301  CGKAFSRSST LTNHKRIHTG ERPYKCEECG KAFSLSSTLK KHKIVHTGEK LYTCEECGKA
   361  FTFSSTLNTH KRIHTGEKPY TCEECGKAFS LPSTFTYHKR THTGEKPYKC EECGKAFNCS
   421  STLKKHKIIH TGEKLYKCKE CGKAFTFSST LNTHKRIHTG EKPYKCEECD QTFKWHSSLA
   481  NHKNMHTGEK PYKYE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF716 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 0.4 nTPM

Expression across tissuesHPA

Tissue

testis: 0.4 nTPM
bone marrow: 0.1 nTPM
epididymis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

differentiating spermatogonia: 9.4 nCPM
late spermatids: 6.3 nCPM
late primary spermatocytes: 5.6 nCPM
early primary spermatocytes: 5 nCPM
undifferentiated spermatogonia: 3.8 nCPM
early spermatids: 3.4 nCPM

Immune cell

basophil: 0.6 nTPM
neutrophil: 0.5 nTPM
NK-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM

Brain region

cerebellum: 1.7 nTPM
cerebral cortex: 1.6 nTPM
choroid plexus: 1.6 nTPM
white matter: 1.6 nTPM
pons: 1.4 nTPM
amygdala: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0
gnomAD missense Z: -0.4
DepMap mean gene effect: 0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF716 as an antibody target. Whether an autoantibody or antibody against ZNF716 could matter depends on whether native ZNF716 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF716 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF716 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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