Seroatlas · Human Serome Atlas

ZNF658

Zinc finger protein 658

Also known as: DKFZp572C163, FLJ32813, MGC35232, ZN658_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TYW1
Gene: ZNF658
Ensembl: ENSG00000274349
Chromosome: 9
Canonical length: 1059 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables transcription cis-regulatory region binding activity. Involved in cellular response to zinc ion; negative regulation of DNA-templated transcription; and ribosome biogenesis. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1059 residues, UniProt reviewed canonical sequence.

>Q5TYW1|ZNF658
     1  MNMSQASVSF QDVTVEFTRE EWQHLGPVER TLYRDVMLEN YSHLISVGYC ITKPKVISKL
    61  EKGEEPWSLE DEFLNQRYPG YFKVDHIKGI REKQEKPLWQ EIFISDADKT LSKEGQKVLE
   121  KPFNLEIAPE LSEKISCKCD SHRMNLPVAS QLIISERKYS RKKTEYMNVC EKLQLDIKHE
   181  KAHAEEKSYE HGENAKAFSY KKDQHWKFQT LEESFECDGS GQGLYDKTIC ITPQSFLTGE
   241  KSCKDDEFRK NFDKITLFNH MRTDTRGKCS DLNEYGTSCD KTTAVEYNKV HMAMTHYECN
   301  ERGINFSRKS PLTQSQRTIT GWSAFESNKC EENFSQSSAH IVHQKTQAGD KFGEHNECTD
   361  ALYQKLDFTA HQRIHTEDKF YLSDEHGKCR KSFYRKAHLI QHQRPHSGEK TYQYEECAKS
   421  FCSSSHPIQH PGTYVGFKLY ECNECGKAFC QNSNLSKHLR IHTKEKPCDN NGCGRSYKSP
   481  LIGHQKTDAE MELCGGSEYG KTSHLKGHQR ILMGEKPYEC IECGKTFSKT SHLRAHQRIH
   541  TGEKPYECVE CEKTFSHKTH LSVHQRVHTG EKPYECNDCG KSFTYNSALR AHQRIHTGEK
   601  PYECSDCEKT FAHNSALRAH HRIHTGEKPY ECNECGRSFA HISVLKAHQR IHTGEKPYEC
   661  NECGRSFTYN SALRAHQRIH TGRKPYECSD CEKTFAHNSA LKIHQRIHTG EKPYECNECE
   721  KTFAHNSALR AHQNIHTGEK LYECSECGKT FFQKTRLSTH RRIHTGEKPY ECSKCGKTFS
   781  QKSYLSGHER IHTGEKPYEC NVCGKTFVYK AALIVHQRIH TGEKPYECNQ CGKTFSQRTH
   841  LCAHQRIHTG EKPYECNECG KTFADNSALR AHHRIHTGEK PYECNDCGKT FSKTSHLRAH
   901  LRTRSGEKPY ECSECGKTFS EKSYVSAHQR VHTGEKPYEC NVCGKPFAHN STLRVHQRIH
   961  TGEKSYECND CGKTFSQKSH LSAHQRIHTG EKPYECNECG KAFAQNSTLR VHQRIHTGEK
  1021  PYECDECGKT FVRKAALRVH HTRMHTREKT LACNGFGKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF658 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 7.9 nTPM

Expression across tissuesHPA

Tissue

skin: 7.9 nTPM
breast: 5.3 nTPM
retina: 5.2 nTPM
ovary: 5.1 nTPM
skeletal muscle: 5.1 nTPM
parathyroid gland: 5 nTPM

Single-cell type

cardiomyocytes: 27 nCPM
distal convoluted tubule cells: 20 nCPM
myonuclei: 19 nCPM
loop of henle epithelial cells: 17 nCPM
proximal tubule cells: 16 nCPM
bergmann glia: 15 nCPM

Immune cell

neutrophil: 28 nTPM
NK-cell: 2.4 nTPM
eosinophil: 2.3 nTPM
naive CD4 T-cell: 1.8 nTPM
naive B-cell: 1.6 nTPM
memory CD4 T-cell: 1.3 nTPM

Brain region

cerebellum: 17 nTPM
hypothalamus: 14 nTPM
choroid plexus: 14 nTPM
basal ganglia: 14 nTPM
cerebral cortex: 13 nTPM
white matter: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0
gnomAD missense Z: -2.86
DepMap mean gene effect: -0.33
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF658 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF658 as an antibody target. Whether an autoantibody or antibody against ZNF658 could matter depends on whether native ZNF658 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF658 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF658 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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