Seroatlas · Human Serome Atlas

ZNF677

Zinc finger protein 677

Also known as: MGC48625, ZN677_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86XU0
Gene
ZNF677
Ensembl
ENSG00000197928
Chromosome
19
Canonical length
584 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Centrosome

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

584 residues, UniProt reviewed canonical sequence.

>Q86XU0|ZNF677
     1  MALSQGLFTF KDVAIEFSQE EWECLDPAQR ALYRDVMLEN YRNLLSLDED NIPPEDDISV
    61  GFTSKGLSPK ENNKEELYHL VILERKESHG INNFDLKEVW ENMPKFDSLW DYDVKNYKGM
   121  PLTCNKNLTH RKDQQHNKSS IHFSLKQSVS IRDSAHQYFI HDKPFIRNLL KLKNNIRYAG
   181  NKYVKCFENK IGLSLQAQLA ELQRFQTGEK MYECNPVEKS INSSSVSPLP PCVKNICNKY
   241  RKILKYPLLH TQYGRTHIRE KSYKCNDCGK AFSKSSNLTN HQRIHSGQRP YKCNECGKAF
   301  NQCSNLTRHQ RVHTGEKPYQ CNICGKVCSQ NSNLASHQRM HTGEKPYKCN ECGKAFIQRS
   361  HLWGHERIHT GEKPYKCNEC DKAFAERSSL TQHKRIHTGE KPYICNECGK AFKQCSHLTR
   421  HQNIHPGEKP HKCNVCGRAF IQSSSLVEHQ RIHTGEKPYK CNKCDKAFIK RSHLWGHQRT
   481  HTGEKPYKCT ECGKAFTERS NLTQHKKIHT GEKPYKCTEC GKAFTQFANL TRHQKIHIEK
   541  KHCKHNIHGN ALFQSSNLGD HQKSYNREKH IKYNETKIKY SSCT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF677 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • testis: 42 nTPM
  • ovary: 14 nTPM
  • thyroid gland: 11 nTPM
  • retina: 11 nTPM
  • heart muscle: 11 nTPM
  • fallopian tube: 10 nTPM

Single-cell type

  • early spermatids: 784 nCPM
  • late spermatids: 539 nCPM
  • late primary spermatocytes: 199 nCPM
  • oocytes: 92 nCPM
  • differentiating spermatogonia: 49 nCPM
  • early primary spermatocytes: 34 nCPM

Immune cell

  • naive B-cell: 23 nTPM
  • plasmacytoid DC: 20 nTPM
  • naive CD4 T-cell: 20 nTPM
  • basophil: 18 nTPM
  • memory B-cell: 16 nTPM
  • NK-cell: 16 nTPM

Brain region

  • cerebellum: 29 nTPM
  • white matter: 24 nTPM
  • basal ganglia: 21 nTPM
  • cerebral cortex: 21 nTPM
  • medulla oblongata: 20 nTPM
  • spinal cord: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.1
gnomAD pLI
0
gnomAD missense Z
-0.08
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF677 as an antibody target. Whether an autoantibody or antibody against ZNF677 could matter depends on whether native ZNF677 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF677 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF677 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF677. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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