GAIN domain superfamily
IPR046338
Definition
This superfamily represents the GAIN domain which contains the GPS motif ([interpro:IPR000203]). The GAIN domain is conserved in all cell-adhesion GPCRs and all PKD1-related proteins [[cite:PMID:22333914], [cite:PMID:23850273]] and is the functional unit for autoproteolysis. The ancient GPS motif exists in primitive ancestor organisms and it needs to be within the context of the GAIN domain to mediate autoproteolysis PMID:23850273. The structure of the GAIN domain from aGPCR latrophilin 1 revealed that it contains an N-terminal subdomain A composed of six-α-helices, and a C-terminal subdomain B that consists of a twisted β-sandwich of 13 β-strands and 2 small α-helices, of which the last 5 β-strands constitute the GPS motif PMID:23850273.
34 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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