S100/Calcium binding protein 7/8-like, conserved site
IPR001751
Definition
The calcium-binding domain found in S100, CaBP7/8 and similar proteins mainly from animals. It is a subfamily of the EF-hand calcium-binding domain PMID:15284904. S100s are small dimeric acidic calcium and zinc-binding proteins abundant in the brain, with S100B playing an important role in modulating the proliferation and differentiation of neurons and glia cells PMID:15006498. S100 proteins have two different types of calcium-binding sites: a low affinity one with a special structure, and a 'normal' EF-hand type high-affinity site. Protein S100-G from humans (formerly known as Calbindin-D9k) also belong to this family of proteins, but it does not form dimers. CaBP-9k is a cytosolic protein expressed in a variety of tissues. Although its precise function is unknown, it appears to be under the control of the steroid hormones oestrogen and progesterone in the female reproductive system PMID:16288660. In the intestine, this protein may be involved in calcium absorption by mediating intracellular diffusion PMID:12520541. Calcium-binding protein 8 from Rattus norvegicus (Rat) regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. It may play a role in the physiology of neurons and is potentially important in memory and learning PMID:19458041.
25 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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