CALN1
Calcium-binding protein 8
Also known as: CABP8, CABP8_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BXU9
- Gene
- CALN1
- Ensembl
- ENSG00000183166
- Chromosome
- 7
- Canonical length
- 261 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Vesicles,Plasma membrane
OverviewNCBI Gene
This gene encodes a protein with high similarity to the calcium-binding proteins of the calmodulin family. The encoded protein contains two EF-hand domains and potential calcium-binding sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
261 residues, UniProt reviewed canonical sequence.
>Q9BXU9|CALN1
1 MRLPEQPGEG KPENEKKGDG GALGGGEEPP RSQAPDFPTW EKMPFHHVTA GLLYKGNYLN
61 RSLSAGSDSE QLANISVEEL DEIREAFRVL DRDGNGFISK QELGMAMRSL GYMPSEVELA
121 IIMQRLDMDG DGQVDFDEFM TILGPKLVSS EGRDGFLGNT IDSIFWQFDM QRITLEELKH
181 ILYHAFRDHL TMKDIENIII NEEESLNETS GNCQTEFEGV HSQKQNRQTC VRKSLICAFA
241 MAFIISVMLI AANQILRSGM ELocalizationUniProt · AlphaFold · HPA
Whether an antibody against CALN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.46
- Highest tissue expression
- 53 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 53 nTPM
- cerebral cortex: 26 nTPM
- thymus: 23 nTPM
- basal ganglia: 18 nTPM
- spinal cord: 17 nTPM
- hippocampal formation: 11 nTPM
Single-cell type
- hematopoietic stem cells: 1,502 nCPM
- brain excitatory neurons: 897 nCPM
- undifferentiated spermatogonia: 644 nCPM
- bergmann glia: 549 nCPM
- differentiating spermatogonia: 455 nCPM
- pituitary stem cells: 454 nCPM
Immune cell
- myeloid DC: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebellum: 110 nTPM
- hypothalamus: 103 nTPM
- pons: 81 nTPM
- white matter: 72 nTPM
- hippocampal formation: 71 nTPM
- medulla oblongata: 58 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.73
- gnomAD pLI
- 0.03
- gnomAD missense Z
- 1.58
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CALN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CALN1 as an antibody target. Whether an autoantibody or antibody against CALN1 could matter depends on whether native CALN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CALN1 is annotated at the cell surface, where native CALN1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label CALN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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