Seroatlas · Human Serome Atlas

CABP7

Calcium-binding protein 7

Also known as: CABP7_HUMAN, MGC57793

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86V35
Gene: CABP7
Ensembl: ENSG00000100314
Chromosome: 22
Canonical length: 215 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. Located in trans-Golgi network membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

215 residues, UniProt reviewed canonical sequence.

>Q86V35|CABP7
     1  MPFHPVTAAL MYRGIYTVPN LLSEQRPVDI PEDELEEIRE AFKVFDRDGN GFISKQELGT
    61  AMRSLGYMPN EVELEVIIQR LDMDGDGQVD FEEFVTLLGP KLSTSGIPEK FHGTDFDTVF
   121  WKCDMQKLTV DELKRLLYDT FCEHLSMKDI ENIIMTEEES HLGTAEECPV DVETCSNQQI
   181  RQTCVRKSLI CAFAIAFIIS VMLIAANQVL RSGMK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CABP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

hippocampal formation: 53 nTPM
cerebellum: 11 nTPM
spinal cord: 5.7 nTPM
adrenal gland: 5.6 nTPM
midbrain: 4.8 nTPM
cerebral cortex: 4.2 nTPM

Single-cell type

epididymal efferent duct ciliated cells: 19 nCPM
pancreatic islet cells: 10 nCPM
cardiomyocytes: 7.4 nCPM
schwann cells: 6.3 nCPM
other brain neurons: 5.4 nCPM
brain excitatory neurons: 5 nCPM

Immune cell

eosinophil: 0.2 nTPM
neutrophil: 0.2 nTPM
non-classical monocyte: 0.2 nTPM
classical monocyte: 0.1 nTPM
gdT-cell: 0.1 nTPM
intermediate monocyte: 0.1 nTPM

Brain region

hippocampal formation: 78 nTPM
cerebral cortex: 70 nTPM
pons: 63 nTPM
medulla oblongata: 58 nTPM
spinal cord: 46 nTPM
cerebellum: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0.15
gnomAD missense Z: 1.43
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

calcium ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CABP7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PI4KB

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CABP7 as an antibody target. Whether an autoantibody or antibody against CABP7 could matter depends on whether native CABP7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CABP7 is annotated at the cell surface, where native CABP7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CABP7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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