Seroatlas · Human Serome Atlas

HRNR

Hornerin

Also known as: FLG3, HORN_HUMAN, S100A16, S100a18

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86YZ3
Gene
HRNR
Ensembl
ENSG00000197915
Chromosome
1
Canonical length
2850 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Predicted to enable calcium ion binding activity and transition metal ion binding activity. Involved in cell envelope organization and establishment of skin barrier. Located in cornified envelope; keratohyalin granule; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2850 residues, UniProt reviewed canonical sequence.

>Q86YZ3|HRNR
     1  MPKLLQGVIT VIDVFYQYAT QHGEYDTLNK AELKELLENE FHQILKNPND PDTVDIILQS
    61  LDRDHNKKVD FTEYLLMIFK LVQARNKIIG KDYCQVSGSK LRDDTHQHQE EQEETEKEEN
   121  KRQESSFSHS SWSAGENDSY SRNVRGSLKP GTESISRRLS FQRDFSGQHN SYSGQSSSYG
   181  EQNSDSHQSS GRGQCGSGSG QSPNYGQHGS GSGQSSSNDT HGSGSGQSSG FSQHKSSSGQ
   241  SSGYSQHGSG SGHSSGYGQH GSRSGQSSRG ERHRSSSGSS SSYGQHGSGS RQSLGHGRQG
   301  SGSRQSPSHV RHGSGSGHSS SHGQHGSGSS YSYSRGHYES GSGQTSGFGQ HESGSGQSSG
   361  YSKHGSGSGH SSSQGQHGST SGQASSSGQH GSSSRQSSSY GQHESASRHS SGRGQHSSGS
   421  GQSPGHGQRG SGSGQSPSSG QHGTGFGRSS SSGPYVSGSG YSSGFGHHES SSEHSSGYTQ
   481  HGSGSGHSSG HGQHGSRSGQ SSRGERQGSS AGSSSSYGQH GSGSRQSLGH SRHGSGSGQS
   541  PSPSRGRHES GSRQSSSYGP HGYGSGRSSS RGPYESGSGH SSGLGHQESR SGQSSGYGQH
   601  GSSSGHSSTH GQHGSTSGQS SSCGQHGATS GQSSSHGQHG SGSSQSSRYG QQGSGSGQSP
   661  SRGRHGSDFG HSSSYGQHGS GSGWSSSNGP HGSVSGQSSG FGHKSGSGQS SGYSQHGSGS
   721  SHSSGYRKHG SRSGQSSRSE QHGSSSGLSS SYGQHGSGSH QSSGHGRQGS GSGHSPSRVR
   781  HGSSSGHSSS HGQHGSGTSC SSSCGHYESG SGQASGFGQH ESGSGQGYSQ HGSASGHFSS
   841  QGRHGSTSGQ SSSSGQHDSS SGQSSSYGQH ESASHHASGR GRHGSGSGQS PGHGQRGSGS
   901  GQSPSYGRHG SGSGRSSSSG RHGSGSGQSS GFGHKSSSGQ SSGYTQHGSG SGHSSSYEQH
   961  GSRSGQSSRS EQHGSSSGSS SSYGQHGSGS RQSLGHGQHG SGSGQSPSPS RGRHGSGSGQ
  1021  SSSYGPYRSG SGWSSSRGPY ESGSGHSSGL GHRESRSGQS SGYGQHGSSS GHSSTHGQHG
  1081  STSGQSSSCG QHGASSGQSS SHGQHGSGSS QSSGYGRQGS GSGQSPGHGQ RGSGSRQSPS
  1141  YGRHGSGSGR SSSSGQHGSG LGESSGFGHH ESSSGQSSSY SQHGSGSGHS SGYGQHGSRS
  1201  GQSSRGERHG SSSGSSSHYG QHGSGSRQSS GHGRQGSGSG HSPSRGRHGS GLGHSSSHGQ
  1261  HGSGSGRSSS RGPYESRSGH SSVFGQHESG SGHSSAYSQH GSGSGHFCSQ GQHGSTSGQS
  1321  STFDQEGSST GQSSSYGHRG SGSSQSSGYG RHGAGSGQSP SRGRHGSGSG HSSSYGQHGS
  1381  GSGWSSSSGR HGSGSGQSSG FGHHESSSWQ SSGCTQHGSG SGHSSSYEQH GSRSGQSSRG
  1441  ERHGSSSGSS SSYGQHGSGS RQSLGHGQHG SGSGQSPSPS RGRHGSGSGQ SSSYSPYGSG
  1501  SGWSSSRGPY ESGSSHSSGL GHRESRSGQS SGYGQHGSSS GHSSTHGQHG STSGQSSSCG
  1561  QHGASSGQSS SHGQHGSGSS QSSGYGRQGS GSGQSPGHGQ RGSGSRQSPS YGRHGSGSGR
  1621  SSSSGQHGSG LGESSGFGHH ESSSGQSSSY SQHGSGSGHS SGYGQHGSRS GQSSRGERHG
  1681  SSSRSSSRYG QHGSGSRQSS GHGRQGSGSG QSPSRGRHGS GLGHSSSHGQ HGSGSGRSSS
  1741  RGPYESRSGH SSVFGQHESG SGHSSAYSQH GSGSGHFCSQ GQHGSTSGQS STFDQEGSST
  1801  GQSSSHGQHG SGSSQSSSYG QQGSGSGQSP SRGRHGSGSG HSSSYGQHGS GSGWSSSSGR
  1861  HGSGSGQSSG FGHHESSSWQ SSGYTQHGSG SGHSSSYEQH GSRSGQSSRG EQHGSSSGSS
  1921  SSYGQHGSGS RQSLGHGQHG SGSGQSPSPS RGRHGSGSGQ SSSYGPYGSG SGWSSSRGPY
  1981  ESGSGHSSGL GHRESRSGQS SGYGQHGSSS GHSSTHGQHG SASGQSSSCG QHGASSGQSS
  2041  SHGQHGSGSS QSSGYGRQGS GSGQSPGHGQ RGSGSRQSPS YGRHGSGSGR SSSSGQHGPG
  2101  LGESSGFGHH ESSSGQSSSY SQHGSGSGHS SGYGQHGSRS GQSSRGERHG SSSGSSSRYG
  2161  QHGSGSRQSS GHGRQGSGSG HSPSRGRHGS GSGHSSSHGQ HGSGSGRSSS RGPYESRSGH
  2221  SSVFGQHESG SGHSSAYSQH GSGSGHFCSQ GQHGSTSGQS STFDQEGSST GQSSSHGQHG
  2281  SGSSQSSSYG QQGSGSGQSP SRGRHGSGSG HSSSYGQHGS GSGWSSSSGR HGSGSGQSSG
  2341  FGHHESSSWQ SSGYTQHGSG SGHSSSYEQH GSRSGQSSRG ERHGSSSGSS SSYGQHGSGS
  2401  RQSLGHGQHG SGSGQSPSPS RGRHGSGSGQ SSSYSPYGSG SGWSSSRGPY ESGSGHSSGL
  2461  GHRESRSGQS SGYGQHGSSS GHSSTHGQHG STSGQSSSCG QHGASSGQSS SHGQHGSGSS
  2521  QSSGYGRQGS GSGQSPGHGQ RGSGSRQSPS YGRHGSGSGR SSSSGQHGSG LGESSGFGHH
  2581  ESSSGQSSSY SQHGSGSGHS SGYGQHGSRS GQSSRGERHG SSSGSSSHYG QHGSGSRQSS
  2641  GHGRQGSGSG QSPSRGRHGS GLGHSSSHGQ HGSGSGRSSS RGPYESRLGH SSVFGQHESG
  2701  SGHSSAYSQH GSGSGHFCSQ GQHGSTSGQS STFDQEGSST GQSSSYGHRG SGSSQSSGYG
  2761  RHGAGSGQSL SHGRHGSGSG QSSSYGQHGS GSGQSSGYSQ HGSGSGQDGY SYCKGGSNHD
  2821  GGSSGSYFLS FPSSTSPYEY VQEQRCYFYQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HRNR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0
Highest tissue expression
0.6 nTPM

Expression across tissuesHPA

Tissue

  • skin: 0.6 nTPM
  • esophagus: 0.5 nTPM
  • kidney: 0.4 nTPM
  • ovary: 0.4 nTPM
  • pancreas: 0.4 nTPM
  • testis: 0.4 nTPM

Single-cell type

  • epicardial cells: 25 nCPM
  • cardiomyocytes: 16 nCPM
  • fibro-adipogenic progenitors: 5.3 nCPM
  • adipocytes: 5.2 nCPM
  • retinal ganglion cells: 3.9 nCPM
  • medullary thymic epithelial cells: 2.4 nCPM

Immune cell

  • plasmacytoid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • medulla oblongata: 8.6 nTPM
  • hypothalamus: 8.5 nTPM
  • pons: 7 nTPM
  • basal ganglia: 6.1 nTPM
  • midbrain: 6.1 nTPM
  • thalamus: 5.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.95
gnomAD pLI
0
gnomAD missense Z
-12
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HRNR as an antibody target. Whether an autoantibody or antibody against HRNR could matter depends on whether native HRNR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HRNR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HRNR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HRNR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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