S100A10

Protein identityUniProt · HPA

UniProt accession

P60903

Gene

S100A10

Ensembl

ENSG00000197747

Chromosome

1

Canonical length

97 aa

Protein class

Predicted membrane proteins, Transporters

Subcellular location

Mitochondria

OverviewNCBI Gene

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

97 residues, UniProt reviewed canonical sequence.

>P60903|S100A10
     1  MPSQMEHAME TMMFTFHKFA GDKGYLTKED LRVLMEKEFP GFLENQKDPL AVDKIMKDLD
    61  QCRDGKVGFQ SFFSLIAGLT IACNDYFVVH MKQKGKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against S100A10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

2,017 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for S100A10 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.66

gnomAD pLI

0.17

gnomAD missense Z

0.68

DepMap mean gene effect

-0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• membrane raft assembly
• mRNA transcription by RNA polymerase II
• positive regulation of exocytosis
• positive regulation of focal adhesion assembly
• positive regulation of GTPase activity
• positive regulation of plasma membrane repair
• positive regulation of plasminogen activation
• positive regulation of stress fiber assembly
• positive regulation of substrate adhesion-dependent cell spreading
• positive regulation of transcription by RNA polymerase II
• protein localization to plasma membrane
• regulation of neurogenesis
• vesicle budding from membrane

Molecular functions

• calcium ion binding
• calcium-dependent protein binding
• protein homodimerization activity
• transmembrane transporter binding

Cellular components

• AnxA2-p11 complex
• cell surface
• cytoplasm
• extracellular exosome
• extracellular matrix
• extracellular region
• nuclear matrix
• plasma membrane
• plasma membrane protein complex
• RNA polymerase II transcription regulator complex

Protein domainsUniProt · Pfam · InterPro

• S100/Calcium binding protein 7/8-like, conserved site
• EF-hand domain pair
• S100/CaBP-9k-type, calcium binding, subdomain
• S-100/ICaBP type calcium binding domain
• Protein S100-A10

KeywordsUniProt

• Acetylation
• Isopeptide bond
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of S100A10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SCN10A
• TASOR
• TRPV5
• TRPV6
• AHNAK
• ANXA2
• ERBB3