Seroatlas · Human Serome Atlas

S100A12

Protein S100-A12

Also known as: CAAF1, CAGC, CGRP, ENRAGE, MRP6, p6, S10AC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P80511
Gene
S100A12
Ensembl
ENSG00000163221
Chromosome
1
Canonical length
92 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to blood
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity. [provided by RefSeq, Nov 2014]

Canonical amino-acid sequenceUniProt

92 residues, UniProt reviewed canonical sequence.

>P80511|S100A12
     1  MTKLEEHLEG IVNIFHQYSV RKGHFDTLSK GELKQLLTKE LANTIKNIKD KAVIDEIFQG
    61  LDANQDEQVD FQEFISLVAI ALKAAHYHTH KE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against S100A12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
3,294 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 3,294 nTPM
  • spleen: 596 nTPM
  • lung: 165 nTPM
  • appendix: 77 nTPM
  • esophagus: 58 nTPM
  • adipose tissue: 51 nTPM

Single-cell type

  • neutrophils: 6,920 nCPM
  • neutrophil progenitors: 4,218 nCPM
  • esophageal apical cells: 1,615 nCPM
  • monocytes: 885 nCPM
  • monocyte progenitors: 543 nCPM
  • esophageal suprabasal cells: 141 nCPM

Immune cell

  • neutrophil: 1,796 nTPM
  • classical monocyte: 1,326 nTPM
  • total PBMC: 1,034 nTPM
  • myeloid DC: 123 nTPM
  • intermediate monocyte: 45 nTPM
  • non-classical monocyte: 9.7 nTPM

Brain region

  • cerebral cortex: 7.2 nTPM
  • pons: 2.9 nTPM
  • choroid plexus: 1.5 nTPM
  • medulla oblongata: 1.4 nTPM
  • basal ganglia: 1.2 nTPM
  • spinal cord: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.44
gnomAD pLI
0.48
gnomAD missense Z
-0.58
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of S100A12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads S100A12 as an antibody target. Whether an autoantibody or antibody against S100A12 could matter depends on whether native S100A12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

S100A12 is annotated at the cell surface, where native S100A12 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label S100A12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/S100A12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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