S100A7A
Protein S100-A7A
Also known as: S100A15, S100A7f, S100A7L1, S1A7A_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q86SG5
- Gene
- S100A7A
- Ensembl
- ENSG00000184330
- Chromosome
- 1
- Canonical length
- 101 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
Enables identical protein binding activity. Predicted to be involved in endothelial cell migration. Predicted to act upstream of or within inflammatory response. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
101 residues, UniProt reviewed canonical sequence.
>Q86SG5|S100A7A
1 MSNTQAERSI IGMIDMFHKY TGRDGKIEKP SLLTMMKENF PNFLSACDKK GIHYLATVFE
61 KKDKNEDKKI DFSEFLSLLG DIAADYHKQS HGAAPCSGGS QLocalizationUniProt · AlphaFold · HPA
Whether an antibody against S100A7A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 6.5 nTPM
Expression across tissuesHPA
Tissue
- cervix: 6.5 nTPM
- esophagus: 5.7 nTPM
- tonsil: 5.5 nTPM
- vagina: 2.6 nTPM
- skin: 2.3 nTPM
- salivary gland: 0.1 nTPM
Single-cell type
- esophageal apical cells: 28 nCPM
- esophageal suprabasal cells: 22 nCPM
- late spermatids: 4.2 nCPM
- suprabasal keratinocytes: 3.8 nCPM
- early spermatids: 2.9 nCPM
- esophageal basal cells: 2.7 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 0.2 nTPM
- cerebral cortex: 0.2 nTPM
- pons: 0.2 nTPM
- medulla oblongata: 0.1 nTPM
- white matter: 0.1 nTPM
- amygdala: 0 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about S100A7A.
Disease | ImmuneIEDB
Conditions an epitope on S100A7A was assayed in.
- invasive ductal carcinoma T cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.94
- gnomAD pLI
- 0
- gnomAD missense Z
- -1.27
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- calcium ion binding
- calcium-dependent protein binding
- identical protein binding
- transition metal ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads S100A7A as an antibody target. Whether an autoantibody or antibody against S100A7A could matter depends on whether native S100A7A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
S100A7A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label S100A7A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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