S100G
Protein S100-G
Also known as: CABP1, CABP9K, CALB3, S100G_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P29377
- Gene
- S100G
- Ensembl
- ENSG00000169906
- Chromosome
- X
- Canonical length
- 79 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
This gene encodes calbindin D9K, a vitamin D-dependent calcium-binding protein. This cytosolic protein belongs to a family of calcium-binding proteins that includes calmodulin, parvalbumin, troponin C, and S100 protein. In the intestine, the protein is vitamin D-dependent and its expression correlates with calcium transport activity. The protein may increase Ca2+ absorption by buffering Ca2+ in the cytoplasm and increase ATP-dependent Ca2+ transport in duodenal basolateral membrane vesicles. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
79 residues, UniProt reviewed canonical sequence.
>P29377|S100G
1 MSTKKSPEEL KRIFEKYAAK EGDPDQLSKD ELKLLIQAEF PSLLKGPNTL DDLFQELDKN
61 GDGEVSFEEF QVLVKKISQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against S100G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.34
- Highest tissue expression
- 224 nTPM
Expression across tissuesHPA
Tissue
- duodenum: 224 nTPM
- small intestine: 22 nTPM
- breast: 1.1 nTPM
- colon: 0.3 nTPM
- appendix: 0.1 nTPM
- bone marrow: 0.1 nTPM
Single-cell type
- retinal ganglion cells: 3.9 nCPM
- cardiomyocytes: 3.4 nCPM
- epicardial cells: 2.3 nCPM
- adipocytes: 2.1 nCPM
- fibro-adipogenic progenitors: 1.5 nCPM
- mast cells: 1.2 nCPM
Immune cell
- naive CD8 T-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebellum: 2.5 nTPM
- hypothalamus: 2.4 nTPM
- medulla oblongata: 2.1 nTPM
- white matter: 2.1 nTPM
- pons: 1.9 nTPM
- basal ganglia: 1.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.84
- gnomAD pLI
- 0.11
- gnomAD missense Z
- 0.38
- DepMap mean gene effect
- 0.11
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads S100G as an antibody target. Whether an autoantibody or antibody against S100G could matter depends on whether native S100G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
S100G is annotated at the cell surface, where native S100G is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label S100G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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