Seroatlas · Human Serome Atlas

S100A11

Protein S100-A11

Also known as: S100C, S10AB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P31949
Gene
S100A11
Ensembl
ENSG00000163191
Chromosome
1
Canonical length
105 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear speckles,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

105 residues, UniProt reviewed canonical sequence.

>P31949|S100A11
     1  MAKISSPTET ERCIESLIAV FQKYAGKDGY NYTLSKTEFL SFMNTELAAF TKNQKDPGVL
    61  DRMMKKLDTN SDGQLDFSEF LNLIGGLAMA CHDSFLKAVP SQKRT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against S100A11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
4,984 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 4,984 nTPM
  • vagina: 1,890 nTPM
  • cervix: 1,727 nTPM
  • urinary bladder: 1,424 nTPM
  • salivary gland: 1,267 nTPM
  • skin: 915 nTPM

Single-cell type

  • esophageal apical cells: 45,082 nCPM
  • esophageal suprabasal cells: 19,553 nCPM
  • extravillous trophoblasts: 8,453 nCPM
  • neutrophils: 7,788 nCPM
  • esophageal basal cells: 6,383 nCPM
  • suprabasal keratinocytes: 5,207 nCPM

Immune cell

  • neutrophil: 17,941 nTPM
  • basophil: 8,002 nTPM
  • eosinophil: 7,237 nTPM
  • total PBMC: 5,298 nTPM
  • non-classical monocyte: 4,902 nTPM
  • classical monocyte: 4,699 nTPM

Brain region

  • white matter: 102 nTPM
  • thalamus: 100 nTPM
  • pons: 84 nTPM
  • medulla oblongata: 84 nTPM
  • spinal cord: 68 nTPM
  • choroid plexus: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.8
gnomAD pLI
0.01
gnomAD missense Z
0.31
DepMap mean gene effect
-0.25
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of S100A11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads S100A11 as an antibody target. Whether an autoantibody or antibody against S100A11 could matter depends on whether native S100A11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

S100A11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label S100A11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/S100A11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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