S100Z
Protein S100-Z
Also known as: Gm625, S100-zeta, S100Z_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WXG8
- Gene
- S100Z
- Ensembl
- ENSG00000171643
- Chromosome
- 5
- Canonical length
- 99 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Centrosome,Cytosol
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Members of the S100 protein family contain 2 calcium-binding EF-hands and exhibit cell-type specific expression patterns. For additional background information on S100 proteins, see MIM 114085.[supplied by OMIM, Mar 2008]
Canonical amino-acid sequenceUniProt
99 residues, UniProt reviewed canonical sequence.
>Q8WXG8|S100Z
1 MPTQLEMAMD TMIRIFHRYS GKERKRFKLS KGELKLLLQR ELTEFLSCQK ETQLVDKIVQ
61 DLDANKDNEV DFNEFVVMVA ALTVACNDYF VEQLKKKGKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against S100Z can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.38
- Highest tissue expression
- 2.9 nTPM
Expression across tissuesHPA
Tissue
- spleen: 2.9 nTPM
- tonsil: 2.3 nTPM
- bone marrow: 2.2 nTPM
- appendix: 1.9 nTPM
- placenta: 1.1 nTPM
- lymph node: 0.9 nTPM
Single-cell type
- microglia: 224 nCPM
- thymocytes: 197 nCPM
- monocytes: 82 nCPM
- hematopoietic stem cells: 72 nCPM
- neutrophils: 68 nCPM
- monocyte progenitors: 62 nCPM
Immune cell
- non-classical monocyte: 40 nTPM
- classical monocyte: 35 nTPM
- intermediate monocyte: 34 nTPM
- eosinophil: 32 nTPM
- myeloid DC: 20 nTPM
- neutrophil: 12 nTPM
Brain region
- cerebral cortex: 3.1 nTPM
- white matter: 2.7 nTPM
- amygdala: 2.5 nTPM
- thalamus: 2.4 nTPM
- medulla oblongata: 1.7 nTPM
- basal ganglia: 1.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.66
- gnomAD pLI
- 0.01
- gnomAD missense Z
- -0.14
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of S100Z in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads S100Z as an antibody target. Whether an autoantibody or antibody against S100Z could matter depends on whether native S100Z is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
S100Z is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label S100Z as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...