S100A3
Protein S100-A3
Also known as: S100E, S10A3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P33764
- Gene
- S100A3
- Ensembl
- ENSG00000188015
- Chromosome
- 1
- Canonical length
- 101 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Golgi apparatus,Plasma membrane,Cytosol
- Quaternary structure
- Homotetramer
OverviewNCBI Gene
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
101 residues, UniProt reviewed canonical sequence.
>P33764|S100A3
1 MARPLEQAVA AIVCTFQEYA GRCGDKYKLC QAELKELLQK ELATWTPTEF RECDYNKFMS
61 VLDTNKDCEV DFVEYVRSLA CLCLYCHEYF KDCPSEPPCS QLocalizationUniProt · AlphaFold · HPA
Whether an antibody against S100A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.4
- Highest tissue expression
- 99 nTPM
Expression across tissuesHPA
Tissue
- skin: 99 nTPM
- esophagus: 19 nTPM
- lung: 19 nTPM
- vagina: 11 nTPM
- cervix: 9.5 nTPM
- kidney: 9.1 nTPM
Single-cell type
- decidual stromal cells: 0.7 nCPM
- endometrial stromal cells: 0.7 nCPM
- endometrial secretory cells: 0.3 nCPM
- basal keratinocytes: 0.2 nCPM
- fibroblasts: 0.2 nCPM
- endometrial ciliated cells: 0.1 nCPM
Immune cell
- plasmacytoid DC: 7.5 nTPM
- non-classical monocyte: 6.3 nTPM
- intermediate monocyte: 3.1 nTPM
- memory B-cell: 0.6 nTPM
- myeloid DC: 0.4 nTPM
- total PBMC: 0.4 nTPM
Brain region
- thalamus: 4.8 nTPM
- midbrain: 1.9 nTPM
- hypothalamus: 1.7 nTPM
- medulla oblongata: 1.6 nTPM
- white matter: 1.6 nTPM
- spinal cord: 1.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.82
- gnomAD pLI
- 0.01
- gnomAD missense Z
- -0.07
- DepMap mean gene effect
- 0.12
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads S100A3 as an antibody target. Whether an autoantibody or antibody against S100A3 could matter depends on whether native S100A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
S100A3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label S100A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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