S100A16
Protein S100-A16
Also known as: DT1P1A7, MGC17528, S100F, S10AG_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96FQ6
- Gene
- S100A16
- Ensembl
- ENSG00000188643
- Chromosome
- 1
- Canonical length
- 103 aa
- Protein class
- Predicted intracellular proteins, Transporters
- Subcellular location
- Plasma membrane,Cytosol
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables calcium ion binding activity and protein homodimerization activity. Predicted to act upstream of or within response to calcium ion. Located in several cellular components, including cytosol; extracellular space; and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
103 residues, UniProt reviewed canonical sequence.
>Q96FQ6|S100A16
1 MSDCYTELEK AVIVLVENFY KYVSKYSLVK NKISKSSFRE MLQKELNHML SDTGNRKAAD
61 KLIQNLDANH DGRISFDEYW TLIGGITGPI AKLIHEQEQQ SSSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against S100A16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.37
- Highest tissue expression
- 2,382 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 2,382 nTPM
- vagina: 679 nTPM
- cervix: 486 nTPM
- skin: 445 nTPM
- salivary gland: 391 nTPM
- liver: 199 nTPM
Single-cell type
- esophageal apical cells: 21,740 nCPM
- esophageal suprabasal cells: 8,393 nCPM
- esophageal basal cells: 2,819 nCPM
- suprabasal keratinocytes: 2,181 nCPM
- basal keratinocytes: 772 nCPM
- gastric progenitor cells: 496 nCPM
Immune cell
- plasmacytoid DC: 0.3 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- thalamus: 105 nTPM
- medulla oblongata: 102 nTPM
- pons: 62 nTPM
- spinal cord: 61 nTPM
- white matter: 59 nTPM
- amygdala: 53 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.89
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.51
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of S100A16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads S100A16 as an antibody target. Whether an autoantibody or antibody against S100A16 could matter depends on whether native S100A16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
S100A16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label S100A16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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