Seroatlas · Human Serome Atlas

S100A5

Protein S100-A5

Also known as: S100D, S10A5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P33763
Gene: S100A5
Ensembl: ENSG00000196420
Chromosome: 1
Canonical length: 92 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

92 residues, UniProt reviewed canonical sequence.

>P33763|S100A5
     1  METPLEKALT TMVTTFHKYS GREGSKLTLS RKELKELIKK ELCLGEMKES SIDDLMKSLD
    61  KNSDQEIDFK EYSVFLTMLC MAYNDFFLED NK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against S100A5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 2.9 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 2.9 nTPM
skin: 2.6 nTPM
kidney: 1.5 nTPM
duodenum: 1.3 nTPM
stomach: 0.9 nTPM
lymph node: 0.8 nTPM

Single-cell type

extravillous trophoblasts: 12 nCPM
urothelial cells: 5.8 nCPM
paneth cells: 3.9 nCPM
ocular epithelial cells: 3.7 nCPM
mast cells: 3.3 nCPM
epicardial cells: 2.3 nCPM

Immune cell

MAIT T-cell: 3.7 nTPM
T-reg: 3.3 nTPM
plasmacytoid DC: 2.5 nTPM
memory CD4 T-cell: 2.1 nTPM
myeloid DC: 1.4 nTPM
eosinophil: 1.3 nTPM

Brain region

cerebellum: 1.5 nTPM
cerebral cortex: 0.9 nTPM
hypothalamus: 0.7 nTPM
pons: 0.7 nTPM
white matter: 0.7 nTPM
thalamus: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.96
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads S100A5 as an antibody target. Whether an autoantibody or antibody against S100A5 could matter depends on whether native S100A5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

S100A5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label S100A5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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