Seroatlas · Human Serome Atlas

FAM47E

Protein FAM47E

Also known as: FA47E_HUMAN, FLJ42946, LOC100129583

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZV65
Gene: FAM47E
Ensembl: ENSG00000189157
Chromosome: 4
Canonical length: 393 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables enzyme activator activity. Involved in protein localization to chromatin and transcription initiation-coupled chromatin remodeling. Located in chromatin; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

393 residues, UniProt reviewed canonical sequence.

>Q6ZV65|FAM47E
     1  MADRRRRLRP GTLAPVREGV NCRSRCFTKH KNGLKFPTSL HSRQLVFPRK GLDDFRKGCP
    61  PCTGLVTQVP VEGFLPQIYH RAPQLAPKKR QIKLLKEADV LSKLSPAQQA RKAFLEDVEA
   121  HLTPHPLALY LNLEEAMPIE LLSKVLEVLD PDRKLEDTWA YCQDTRKGMK EPTKLLKKHS
   181  TQVYLGPSKK TSVSNAGQWL YEEKPHKMDL LHENGPRPGL HENGISDIDE EFILKQFDID
   241  YETKPSHDAL HTMKLNQVPL ELKRSVGLSK LQETEFFQKL GYERKLQKPQ NPYKPKWVKM
   301  RYGAWYLNPK LWKKQRVDEP LVDPEVSHKA QEENFKKELQ EQEELLADLH GTVAFKDFIL
   361  SRGYRTPRFL ENMYIGKECK RACNKTPIKR TQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM47E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 18 nTPM
spinal cord: 11 nTPM
epididymis: 10 nTPM
hypothalamus: 9.3 nTPM
pancreas: 9.1 nTPM
thyroid gland: 9 nTPM

Single-cell type

ependymal cells: 49 nCPM
choroid plexus epithelial cells: 43 nCPM
astrocytes: 21 nCPM
oligodendrocytes: 19 nCPM
bergmann glia: 18 nCPM
other brain neurons: 16 nCPM

Immune cell

naive B-cell: 1.3 nTPM
plasmacytoid DC: 0.6 nTPM
classical monocyte: 0.1 nTPM
MAIT T-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

hypothalamus: 18 nTPM
white matter: 17 nTPM
midbrain: 16 nTPM
cerebral cortex: 16 nTPM
medulla oblongata: 15 nTPM
choroid plexus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: 1.84
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

enzyme activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM47E in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM47E as an antibody target. Whether an autoantibody or antibody against FAM47E could matter depends on whether native FAM47E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM47E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM47E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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