Seroatlas · Human Serome Atlas

SUZ12

Polycomb protein SUZ12

Also known as: CHET9, JJAZ1, KIAA0160, SUZ12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15022
Gene
SUZ12
Ensembl
ENSG00000178691
Chromosome
17
Canonical length
739 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Nucleoli rim,Nuclear bodies

OverviewNCBI Gene

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]

Canonical amino-acid sequenceUniProt

739 residues, UniProt reviewed canonical sequence.

>Q15022|SUZ12
     1  MAPQKHGGGG GGGSGPSAGS GGGGFGGSAA VAAATASGGK SGGGSCGGGG SYSASSSSSA
    61  AAAAGAAVLP VKKPKMEHVQ ADHELFLQAF EKPTQIYRFL RTRNLIAPIF LHRTLTYMSH
   121  RNSRTNIKRK TFKVDDMLSK VEKMKGEQES HSLSAHLQLT FTGFFHKNDK PSPNSENEQN
   181  SVTLEVLLVK VCHKKRKDVS CPIRQVPTGK KQVPLNPDLN QTKPGNFPSL AVSSNEFEPS
   241  NSHMVKSYSL LFRVTRPGRR EFNGMINGET NENIDVNEEL PARRKRNRED GEKTFVAQMT
   301  VFDKNRRLQL LDGEYEVAMQ EMEECPISKK RATWETILDG KRLPPFETFS QGPTLQFTLR
   361  WTGETNDKST APIAKPLATR NSESLHQENK PGSVKPTQTI AVKESLTTDL QTRKEKDTPN
   421  ENRQKLRIFY QFLYNNNTRQ QTEARDDLHC PWCTLNCRKL YSLLKHLKLC HSRFIFNYVY
   481  HPKGARIDVS INECYDGSYA GNPQDIHRQP GFAFSRNGPV KRTPITHILV CRPKRTKASM
   541  SEFLESEDGE VEQQRTYSSG HNRLYFHSDT CLPLRPQEME VDSEDEKDPE WLREKTITQI
   601  EEFSDVNEGE KEVMKLWNLH VMKHGFIADN QMNHACMLFV ENYGQKIIKK NLCRNFMLHL
   661  VSMHDFNLIS IMSIDKAVTK LREMQQKLEK GESASPANEE ITEEQNGTAN GFSEINSKEK
   721  ALETDSVSGV SKQSKKQKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUZ12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
43 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 43 nTPM
  • thymus: 36 nTPM
  • lymph node: 31 nTPM
  • tonsil: 28 nTPM
  • testis: 26 nTPM
  • retina: 25 nTPM

Single-cell type

  • erythrocyte progenitors: 244 nCPM
  • neutrophil progenitors: 214 nCPM
  • monocyte progenitors: 208 nCPM
  • megakaryocyte progenitors: 197 nCPM
  • early primary spermatocytes: 195 nCPM
  • differentiating spermatogonia: 164 nCPM

Immune cell

  • memory B-cell: 2.4 nTPM
  • naive CD8 T-cell: 2.1 nTPM
  • NK-cell: 1.9 nTPM
  • plasmacytoid DC: 1.9 nTPM
  • naive B-cell: 1.8 nTPM
  • T-reg: 1.8 nTPM

Brain region

  • cerebellum: 26 nTPM
  • white matter: 18 nTPM
  • choroid plexus: 17 nTPM
  • thalamus: 16 nTPM
  • amygdala: 16 nTPM
  • basal ganglia: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SUZ12.

Disease | AllUniProt

Conditions SUZ12 is implicated in, by any mechanism.

Disease | GeneticClinVar

34 pathogenic / likely-pathogenic of 220 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.13
gnomAD pLI
1
gnomAD missense Z
3.4
DepMap mean gene effect
-0.48
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Polycomb protein, VEFS-Box
  • Polycomb protein SUZ12-like, zinc finger domain
  • VEFS-Box of polycomb protein
  • Polycomb protein SUZ12-like, Zn domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SUZ12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUZ12 as an antibody target. Whether an autoantibody or antibody against SUZ12 could matter depends on whether native SUZ12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUZ12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SUZ12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SUZ12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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