Seroatlas · Human Serome Atlas

TSC22D2

TSC22 domain family protein 2

Also known as: KIAA0669, T22D2_HUMAN, TILZ4a, TILZ4b, TILZ4c

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75157
Gene
TSC22D2
Ensembl
ENSG00000196428
Chromosome
3
Canonical length
780 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Cytosol

OverviewNCBI Gene

Involved in negative regulation of cell cycle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

780 residues, UniProt reviewed canonical sequence.

>O75157|TSC22D2
     1  MSKMPAKKKS CFQITSVTTA QVATSITEDT ESLDDPDESR TEDVSSEIFD VSRATDYGPE
    61  EVCERSSSEE TLNNVGDAET PGTVSPNLLL DGQLAAAAAA PANGGGVVSA RSVSGALAST
   121  LAAAATSAPA PGAPGGPQLA GSSAGPVTAA PSQPPTTCSS RFRVIKLDHG SGEPYRRGRW
   181  TCMEYYERDS DSSVLTRSGD CIRHSSTFDQ TAERDSGLGA TGGSVVVVVA SMQGAHGPES
   241  GTDSSLTAVS QLPPSEKMSQ PTPAQPQSFS VGQPQPPPPP VGGAVAQSSA PLPPFPGAAT
   301  GPQPMMAAAQ PSQPQGAGPG GQTLPPTNVT LAQPAMSLPP QPGPAVGAPA AQQPQQFAYP
   361  QPQIPPGHLL PVQPSGQSEY LQQHVAGLQP PSPAQPSSTG AAASPATAAT LPVGTGQNAS
   421  SVGAQLMGAS SQPSEAMAPR TGPAQGGQVA PCQPTGVPPA TVGGVVQPCL GPAGAGQPQS
   481  VPPPQMGGSG PLSAVPGGPH AVVPGVPNVP AAVPAPSVPS VSTTSVTMPN VPAPLAQSQQ
   541  LSSHTPVSRS SSIIQHVGLP LAPGTHSAPT SLPQSDLSQF QTQTQPLVGQ VDDTRRKSEP
   601  LPQPPLSLIA ENKPVVKPPV ADSLANPLQL TPMNSLATSV FSIAIPVDGD EDRNPSTAFY
   661  QAFHLNTLKE SKSLWDSASG GGVVAIDNKI EQAMDLVKSH LMYAVREEVE VLKEQIKELV
   721  ERNSLLEREN ALLKSLSSND QLSQLPTQQA NPGSTSQQQA VIAQPPQPTQ PPQQPNVSSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSC22D2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 33 nTPM
  • liver: 28 nTPM
  • smooth muscle: 25 nTPM
  • endometrium: 22 nTPM
  • gallbladder: 21 nTPM
  • esophagus: 20 nTPM

Single-cell type

  • ocular epithelial cells: 932 nCPM
  • distal convoluted tubule cells: 907 nCPM
  • urothelial cells: 654 nCPM
  • esophageal apical cells: 510 nCPM
  • neutrophils: 479 nCPM
  • smooth muscle cells: 441 nCPM

Immune cell

  • non-classical monocyte: 2.9 nTPM
  • neutrophil: 2.2 nTPM
  • eosinophil: 2 nTPM
  • NK-cell: 2 nTPM
  • MAIT T-cell: 1.8 nTPM
  • classical monocyte: 1.7 nTPM

Brain region

  • cerebral cortex: 42 nTPM
  • white matter: 36 nTPM
  • cerebellum: 35 nTPM
  • pons: 34 nTPM
  • midbrain: 34 nTPM
  • medulla oblongata: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.97
gnomAD missense Z
0.7
DepMap mean gene effect
-0.41
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of TSC22D2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSC22D2 as an antibody target. Whether an autoantibody or antibody against TSC22D2 could matter depends on whether native TSC22D2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSC22D2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSC22D2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TSC22D2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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