NKX3-1
Homeobox protein Nkx-3.1
Also known as: BAPX2, NKX3.1, NKX31_HUMAN, NKX3A
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q99801
- Gene
- NKX3-1
- Ensembl
- ENSG00000167034
- Chromosome
- 8
- Canonical length
- 234 aa
- Protein class
- Cancer-related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]
Canonical amino-acid sequenceUniProt
234 residues, UniProt reviewed canonical sequence.
>Q99801|NKX3-1
1 MLRVPEPRPG EAKAEGAAPP TPSKPLTSFL IQDILRDGAQ RQGGRTSSQR QRDPEPEPEP
61 EPEGGRSRAG AQNDQLSTGP RAAPEEAETL AETEPERHLG SYLLDSENTS GALPRLPQTP
121 KQPQKRSRAA FSHTQVIELE RKFSHQKYLS APERAHLAKN LKLTETQVKI WFQNRRYKTK
181 RKQLSSELGD LEKHSSLPAL KEEAFSRASL VSVYNSYPYY PYLYCVGSWS PAFWLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NKX3-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.62
- Highest tissue expression
- 285 nTPM
Expression across tissuesHPA
Tissue
- prostate: 285 nTPM
- salivary gland: 59 nTPM
- testis: 22 nTPM
- liver: 3.8 nTPM
- adrenal gland: 3.7 nTPM
- tongue: 3.6 nTPM
Single-cell type
- prostatic glandular cells: 1,232 nCPM
- submucosal glandular cells: 63 nCPM
- basal prostatic cells: 51 nCPM
- epididymal basal cells: 50 nCPM
- sertoli cells: 40 nCPM
- prostatic club cells: 22 nCPM
Immune cell
- eosinophil: 54 nTPM
- neutrophil: 52 nTPM
- basophil: 10 nTPM
- naive CD8 T-cell: 2.5 nTPM
- memory B-cell: 2.2 nTPM
- naive B-cell: 1.8 nTPM
Brain region
- medulla oblongata: 3.6 nTPM
- spinal cord: 3.5 nTPM
- hypothalamus: 3.2 nTPM
- pons: 3.1 nTPM
- midbrain: 2.9 nTPM
- cerebellum: 2.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.38
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.22
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- none
OntologyGO
Biological processes
- androgen receptor signaling pathway
- branching involved in prostate gland morphogenesis
- branching morphogenesis of an epithelial tube
- cell differentiation
- cellular response to hypoxia
- cellular response to interleukin-1
- cellular response to steroid hormone stimulus
- cellular response to tumor necrosis factor
- cellular response to xenobiotic stimulus
- DNA damage response
- dorsal aorta development
- epithelial cell proliferation involved in prostate gland development
- epithelial cell proliferation involved in salivary gland morphogenesis
- heart development
- male gonad development
- metanephros development
- negative regulation of DNA-templated transcription
- negative regulation of epithelial cell proliferation
- negative regulation of epithelial cell proliferation involved in prostate gland development
- negative regulation of gene expression
- negative regulation of insulin-like growth factor receptor signaling pathway
- negative regulation of transcription by RNA polymerase II
- pharyngeal system development
- positive regulation of cell division
- positive regulation of cell population proliferation
- positive regulation of DNA-templated transcription
- positive regulation of gene expression
- positive regulation of intrinsic apoptotic signaling pathway
- positive regulation of mitotic cell cycle
- positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- positive regulation of transcription by RNA polymerase II
- regulation of DNA-templated transcription
- regulation of protein localization
- regulation of transcription by RNA polymerase II
- response to testosterone
- salivary gland development
- somitogenesis
- positive regulation of androgen secretion
Molecular functions
- cysteine-type endopeptidase activator activity involved in apoptotic process
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription factor binding
- histone deacetylase binding
- nuclear estrogen receptor binding
- nuclear receptor activity
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
- transcription cis-regulatory region binding
- transcription regulator inhibitor activity
- MADS box domain binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of NKX3-1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NKX3-1 as an antibody target. Whether an autoantibody or antibody against NKX3-1 could matter depends on whether native NKX3-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NKX3-1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NKX3-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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