Seroatlas · Human Serome Atlas

WIPF1

WAS/WASL-interacting protein family member 1

Also known as: WASPIP, WIP, WIPF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43516
Gene
WIPF1
Ensembl
ENSG00000115935
Chromosome
2
Canonical length
503 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

503 residues, UniProt reviewed canonical sequence.

>O43516|WIPF1
     1  MPVPPPPAPP PPPTFALANT EKPTLNKTEQ AGRNALLSDI SKGKKLKKTV TNDRSAPILD
    61  KPKGAGAGGG GGGFGGGGGF GGGGGGGGGG SFGGGGPPGL GGLFQAGMPK LRSTANRDND
   121  SGGSRPPLLP PGGRSTSAKP FSPPSGPGRF PVPSPGHRSG PPEPQRNRMP PPRPDVGSKP
   181  DSIPPPVPST PRPIQSSPHN RGSPPVPGGP RQPSPGPTPP PFPGNRGTAL GGGSIRQSPL
   241  SSSSPFSNRP PLPPTPSRAL DDKPPPPPPP VGNRPSIHRE AVPPPPPQNN KPPVPSTPRP
   301  SASSQAPPPP PPPSRPGPPP LPPSSSGNDE TPRLPQRNLS LSSSTPPLPS PGRSGPLPPP
   361  PSERPPPPVR DPPGRSGPLP PPPPVSRNGS TSRALPATPQ LPSRSGVDSP RSGPRPPLPP
   421  DRPSAGAPPP PPPSTSIRNG FQDSPCEDEW ESRFYFHPIS DLPPPEPYVQ TTKSYPSKLA
   481  RNESRSGSNR RERGAPPLPP IPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WIPF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.72
Highest tissue expression
107 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 107 nTPM
  • tonsil: 93 nTPM
  • appendix: 85 nTPM
  • spleen: 80 nTPM
  • spinal cord: 60 nTPM
  • thymus: 60 nTPM

Single-cell type

  • neutrophils: 1,272 nCPM
  • platelets: 899 nCPM
  • nk-cells: 493 nCPM
  • neutrophil progenitors: 474 nCPM
  • t-cells: 469 nCPM
  • monocytes: 357 nCPM

Immune cell

  • neutrophil: 158 nTPM
  • eosinophil: 82 nTPM
  • memory CD8 T-cell: 65 nTPM
  • gdT-cell: 65 nTPM
  • T-reg: 54 nTPM
  • NK-cell: 54 nTPM

Brain region

  • white matter: 74 nTPM
  • medulla oblongata: 74 nTPM
  • pons: 63 nTPM
  • midbrain: 61 nTPM
  • thalamus: 60 nTPM
  • hypothalamus: 59 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WIPF1.

Disease | AllUniProt

Conditions WIPF1 is implicated in, by any mechanism.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 381 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Wiskott-Aldrich syndrome 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.9
gnomAD missense Z
1.15
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WIPF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WIPF1 as an antibody target. Whether an autoantibody or antibody against WIPF1 could matter depends on whether native WIPF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WIPF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WIPF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WIPF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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